ODN 2216,97.88%
产品编号：Bellancom-150741| CAS NO：332437-00-0| 分子量：6432.00
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ODN 2216
| 产品介绍 | ODN 2216 是一种 TLR9 (toll 样受体 9) 配体或激动剂。ODN 2216 诱导大量的 IFN-α 和 IFN-β。ODN 2216 通过 pDC (浆细胞样 DC) 诱导 IFN-α，并通过 DC (树突状细胞)产生 IL-12 (p40)。ODN 2216 刺激外周血单核细胞 (PBMC) 产生 IFN-γ，这是间接的和由 IFN-α/β 介导的。ODN 2216 可以激活 NK 细胞，促进 IFN-γ 产生 TCR 触发的 CD4+ T 细胞。 | ||||||||
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| 生物活性 | ODN 2216 is a TLR9 (toll-like receptor 9) ligand or agonist. ODN 2216 induces high amounts of IFN-α and IFN-β. ODN 2216 induces IFN-α by pDC (plasmacytoid DC) and IL-12 (p40) production by DC (dendritic cells). ODN 2216 stimulates IFN-γ production in peripheral blood mononuclear cells (PBMC), which is indirect and mediated by IFN-α/β. ODN 2216 can activate NK cells and promote IFN-γ production of TCR-triggered CD4+ T cells[4]. | ||||||||
| 体外研究 |
ODN 2216 (6 μg/mL, 9 days) drives Th1 development of naive CD4 T cells. 西域 has not independently confirmed the accuracy of these methods. They are for reference only. Apoptosis Analysis
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| 体内研究 (In Vivo) |
ODN 2216 induces T-cell mediated antitumor immune response in murine vaccination models 西域 has not independently confirmed the accuracy of these methods. They are for reference only. | ||||||||
| 体内研究 |
ODN 2216 induces T-cell mediated antitumor immune response in murine vaccination models 西域 has not independently confirmed the accuracy of these methods. They are for reference only. | ||||||||
| 体内研究 |
ODN 2216 induces T-cell mediated antitumor immune response in murine vaccination models 西域 has not independently confirmed the accuracy of these methods. They are for reference only. | ||||||||
| 性状 | Solid | ||||||||
| 溶解性数据 | |||||||||
| 运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||
| 储存方式 |
-20°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) | ||||||||
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