PSB-603|cas:1092351-10-4|西域试剂

PSB-603,98.13%

产品编号：Bellancom-103166| CAS NO：1092351-10-4| 分子式：C₂₄H₂₅ClN₆O₄S| 分子量：529.01

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货号	价格	库存与货期
Bellancom-103166	￥3300.00	杭州北京（现货）
Bellancom-103166	￥5300.00	杭州北京（现货）
Bellancom-103166	￥9850.00	杭州北京（现货）

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PSB-603

产品介绍

PSB-603 是一种有效的高选择性 A_2B 腺苷受体拮抗剂，K_i 为 0.553 nM，对人和大鼠 A₁ 和 A_2A 以及人 A₃ 受体几乎没有亲和力。

生物活性

PSB-603 is a potent and highly selective A_2B adenosine receptor antagonist exhibiting a K_i value of 0.553 nM and virtually no affinity for the human and rat A₁ and A_2A and the human A₃ receptors up to a concentration of 10 μM.

体外研究

PSB-603 is a potent and selective adenosine A2B receptor antagonist exhibiting a Ki value of 0.553 nM at the human A2B receptor and virtually no affinity for the human and rat A1 and A2A and the human A3 receptors up to a concentration of 10 μM.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay

Cell Line:	Peripheral T cells
Concentration:	100 nM
Incubation Time:	24 hours
Result:	Significantly inhibited NECA stimulated IL-6 release ≈3-fold.

体内研究
(In Vivo)

PSB-603 shows anti-inflammatory effect in local and systemic inflammation models. PSB-603 (5 mg/kg b.w. ip) significantly reduces inflammation in two mice models of inflammation (local and systemic). PSB-603 significantly decreases levels of the inflammatory cytokines IL-6, TNF-α and of ROS in the inflamed paw and reduces inflammation of the peritoneum by significantly decreasing the infiltration of leukocytes^[4]. PSB-603 is administered as suspensions in 1 % Tween 80^[4].

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Adult male Albino Swiss mice, CD-1, weighing 25-30 g^[4]
Dosage:	1, 5 or 10 mg/kg
Administration:	Administered intraperitoneally (ip), prior to carrageenan injection
Result:	Carrageenan-induced edema model. The increase in paw oedema was significantly inhibited in all groups receiving PSB-603. The dose of 5 mg/kg turned out to be the most active.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Adult male Albino Swiss mice, CD-1, weighing 25-30 g^[4]
Dosage:	1, 5 or 10 mg/kg
Administration:	Administered intraperitoneally (ip), prior to carrageenan injection
Result:	Carrageenan-induced edema model. The increase in paw oedema was significantly inhibited in all groups receiving PSB-603. The dose of 5 mg/kg turned out to be the most active.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Adult male Albino Swiss mice, CD-1, weighing 25-30 g^[4]
Dosage:	1, 5 or 10 mg/kg
Administration:	Administered intraperitoneally (ip), prior to carrageenan injection
Result:	Carrageenan-induced edema model. The increase in paw oedema was significantly inhibited in all groups receiving PSB-603. The dose of 5 mg/kg turned out to be the most active.

性状

Solid

溶解性数据

In Vitro:

DMSO : 32.5 mg/mL (61.44 mM; ultrasonic and warming and heat to 60°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.8903 mL	9.4516 mL	18.9032 mL
5 mM	0.3781 mL	1.8903 mL	3.7806 mL
10 mM	0.1890 mL	0.9452 mL	1.8903 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式