Isoallolithocholic acid 3β-Hydroxy-5α-cholanic acid|cas:2276-93-9|西域试剂

Isoallolithocholic acid 3β-Hydroxy-5α-cholanic acid,98.0%

产品编号：Bellancom-B0172A| CAS NO：2276-93-9| 分子式：C₂₄H₄₀O₃| 分子量：376.57

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货号	价格	库存与货期
Bellancom-B0172A	￥2400.00	杭州北京（现货）
Bellancom-B0172A	￥3800.00	杭州北京（现货）
Bellancom-B0172A	￥7600.00	杭州北京（现货）
Bellancom-B0172A	￥12200.00	杭州北京（现货）

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Isoallolithocholic acid 3β-Hydroxy-5α-cholanic acid

产品介绍

Isoallolithocholic acid (3β-Hydroxy-5α-cholanic acid)，Lithocholic acid (HY-10219) 的衍生物，是一种 T 细胞调节剂。Isoallolithocholic acid 增强调节性 T 细胞 (Tregs) 的分化。

生物活性

Isoallolithocholic acid (3β-Hydroxy-5α-cholanic acid), a derivative of Lithocholic acid (HY-10219), is a T cell regulator. Isoallolithocholic acid enhances regulatory T cells (Tregs) differentiation.

体外研究

Isoallolithocholic acid (3β-Hydroxy-5α-cholanic acid) (20 μM) reduces Th17 cell differentiation by ~50% without affecting RORγt expression.
Isoallolithocholic acid does not affect T cell differentiation into Th1 or Th2 cells, the modulatory effect of Isoallolithocholic acid on Tregs is cell-type specific.
Isoallolithocholic acid-dependent enhanced expression of FoxP3 requires mitoROS.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Isoallolithocholic acid (0.03%; in diet; 7 days) enhances Treg cells in B6 mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Segmented filamentous bacteria (SFB)-colonized Jax-B6 mice
Dosage:	0.03% (w/w)
Administration:	In diet, 7 days
Result:	Was insufficient to enhance Treg percentages both at steady state and following anti-CD3 treatment alone. Significantly enhanced the Treg population in mice treated with anti-CD3 compared to control diet in combination with 0.3% (w/w) 3-oxolithocholic acid (3-oxoLCA). Reduced the number of CD45.1⁺ T effector cells.

体内研究

Isoallolithocholic acid (0.03%; in diet; 7 days) enhances Treg cells in B6 mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Segmented filamentous bacteria (SFB)-colonized Jax-B6 mice
Dosage:	0.03% (w/w)
Administration:	In diet, 7 days
Result:	Was insufficient to enhance Treg percentages both at steady state and following anti-CD3 treatment alone. Significantly enhanced the Treg population in mice treated with anti-CD3 compared to control diet in combination with 0.3% (w/w) 3-oxolithocholic acid (3-oxoLCA). Reduced the number of CD45.1⁺ T effector cells.

性状

Solid

溶解性数据

In Vitro:

DMSO : 83.33 mg/mL (221.29 mM; ultrasonic and warming and heat to 60°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.6555 mL	13.2777 mL	26.5555 mL
5 mM	0.5311 mL	2.6555 mL	5.3111 mL
10 mM	0.2656 mL	1.3278 mL	2.6555 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式