DPTIP|cas:351353-48-5|西域试剂

DPTIP,99.42%

产品编号：Bellancom-131002| CAS NO：351353-48-5| 分子式：C₂₁H₁₈N₂O₃S| 分子量：378.44

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货号	价格	库存与货期
Bellancom-131002	￥1200.00	杭州北京（现货）
Bellancom-131002	￥1900.00	杭州北京（现货）
Bellancom-131002	￥3800.00	杭州北京（现货）
Bellancom-131002	￥6200.00	杭州北京（现货）
Bellancom-131002	￥9800.00	杭州北京（现货）

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DPTIP

产品介绍

DPTIP 是有效的、可透过血脑屏障的中性鞘磷脂酶 (N-SMase 2) (外泌体抑制剂)，其 IC₅₀ 值为 30 nM。

生物活性

DPTIP is a potent brain penetrant neutral sphingomyelinase 2 (N-SMase 2) inhibitor (exosome inhibitor), with an IC₅₀ of 30 nM.

体外研究

DPTIP blocks EV secretion in a dose dependent manner (0.03-30 μM), and at 30 μM, this compound could decrease exosome release by 50% in astrocytes.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

DPTIP potently (10 mg/kg IP) inhibits IL-1β-induced astrocyte-derived EV release.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Mice.
Dosage:	10 mg/kg.
Administration:	IP 0.5 h prior to IL-1β striatal injection.
Result:	Brain concentrations of DPTIP are above its IC50 for nSMase2 inhibition for at least 4 h after compound administration. The number of astrocyte-derived EVs was reduced by 51 ± 13% 2 h post IL-1β administration.

体内研究

DPTIP potently (10 mg/kg IP) inhibits IL-1β-induced astrocyte-derived EV release.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Mice.
Dosage:	10 mg/kg.
Administration:	IP 0.5 h prior to IL-1β striatal injection.
Result:	Brain concentrations of DPTIP are above its IC50 for nSMase2 inhibition for at least 4 h after compound administration. The number of astrocyte-derived EVs was reduced by 51 ± 13% 2 h post IL-1β administration.

性状

Solid

溶解性数据

In Vitro:

DMSO : 250 mg/mL (660.61 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.6424 mL	13.2121 mL	26.4243 mL
5 mM	0.5285 mL	2.6424 mL	5.2849 mL
10 mM	0.2642 mL	1.3212 mL	2.6424 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式