BMS-986120|cas:1478712-37-6|西域试剂

BMS-986120,98.54%

产品编号：Bellancom-19837| CAS NO：1478712-37-6| 分子式：C₂₃H₂₃N₅O₅S₂| 分子量：513.59

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货号	价格	库存与货期
Bellancom-19837	￥3500.00	杭州北京（现货）
Bellancom-19837	￥5500.00	杭州北京（现货）
Bellancom-19837	￥11000.00	杭州北京（现货）

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BMS-986120

产品介绍

BMS-986120 是first-in-class、具有口服活性的蛋白酶激活受体 4 (PAR4) 的可逆拮抗剂，在人类和猴子血液中的 IC₅₀ 值分别为 9.5 nM 和 2.1 nM。BMS-986120 具有有效选择性的抗血小板作用。

生物活性

BMS-986120 is a first-in-class oral and reversible protease-activated receptor 4 (PAR4) antagonist, with IC₅₀s of 9.5 nM and 2.1 nM in human and monkey blood, respectively. BMS-986120 has potent and selective antiplatelet effects.

体外研究

BMS-986120 has high binding affinity to PAR4 expressed on HEK293 cells and inhibition of PAR4-induced calcium mobilization with an IC₅₀ of 0.56 nM.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

In monkeys, BMS (1 mg/kg) does not inhibit PA induced by PAR1-AP, ADP and collagen, supporting selectivity. BMS (0.2, 0.5, 1 mg/kg) reduces TW by 35±5, 49±4, and 83±4%, respectively. Maximum KBT and MBT increases are only 2.2-fold and 1.8-fold, respectively.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : 3.33 mg/mL (6.48 mM; ultrasonic and warming and heat to 80°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.9471 mL	9.7354 mL	19.4708 mL
5 mM	0.3894 mL	1.9471 mL	3.8942 mL
10 mM	---	---	---

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式