IZCZ-3|cas:2223019-53-0|西域试剂

IZCZ-3,98.13%

产品编号：Bellancom-111411| CAS NO：2223019-53-0| 分子式：C₄₆H₄₉N₇O| 分子量：715.93

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货号	价格	库存与货期
Bellancom-111411	￥4000.00	杭州北京（现货）
Bellancom-111411	￥6800.00	杭州北京（现货）
Bellancom-111411	￥19500.00	杭州北京（现货）
Bellancom-111411	￥29000.00	杭州北京（现货）

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IZCZ-3

产品介绍

IZCZ-3 是有效的 c-MYC 转录抑制剂，具有抗肿瘤活性。

生物活性

IZCZ-3 is a potent c-MYC transcription inhibitor with antitumor activity.

体外研究

IZCZ-3 (2.1 μM-15.9 μM; 24 hours) significantly inhibits SiHa, HeLa, Huh7, and A375 cancer cell proliferation (IC₅₀s of 3.3, 2.1，4.1, and 4.2 μM, respectively). IZCZ-3 induces only weak growth inhibition in the BJ fibroblasts (IC₅₀=15.9 μM) and mouse mesangial cells (IC₅₀=15.6 μM), suggesting that IZCZ-3 is more effective against cancer cells than against c-MYC-independent normal cells.
IZCZ-3 (0-5 μM; 12 hours) induces an apparent accumulation of cells in the G0/G1 phase in SiHa cells in a dose-dependent manner.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay

Cell Line:	SiHa, HeLa, Huh7, and A375 cancer cells (with overexpression of c-MYC protein) and in normal BJ fibroblasts and primary cultured mouse mesangial cells (with relatively low expression of c-MYC protein).
Concentration:	2.1 μM-15.9 μM
Incubation Time:	24 hours
Result:	IC₅₀s of 3.3, 2.1，4.1, and 4.2 μM for SiHa, HeLa, Huh7, and A375 cancer cells; IC₅₀s of 15.9 μM and 15.6 μM for BJ fibroblasts and mouse mesangial cells.

Cell Cycle Analysis

Cell Line:	SiHa cells
Concentration:	0, 1.25, 2.5, and 5 μM
Incubation Time:	12 hours
Result:	Induced an apparent accumulation of cells in the G0/G1 phase (increasing from 61% to 70%) in a dose-dependent manner.

体内研究
(In Vivo)

IZCZ-3 (20, 10, and 5 mg/kg; intraperitoneally; every other day for 24 days) inhibits tumor growth in BALB/c nude mice with SiHa human cervical squamous cancer xenograft.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	BALB/c nude mice (5 weeks old) bearing SiHa human cervical squamous cancer xenograft model
Dosage:	20, 10, and 5 mg/kg
Administration:	Treated intraperitoneally; every other day for 24 days
Result:	Treatment with 20, 10, and 5 mg/kg resulted in a significant reduction in tumor weight with tumor growth inhibition (TGI) of 69%, 64%, and 57%, respectively. Displayed time-dependent inhibition of tumor growth.

体内研究

IZCZ-3 (20, 10, and 5 mg/kg; intraperitoneally; every other day for 24 days) inhibits tumor growth in BALB/c nude mice with SiHa human cervical squamous cancer xenograft.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	BALB/c nude mice (5 weeks old) bearing SiHa human cervical squamous cancer xenograft model
Dosage:	20, 10, and 5 mg/kg
Administration:	Treated intraperitoneally; every other day for 24 days
Result:	Treatment with 20, 10, and 5 mg/kg resulted in a significant reduction in tumor weight with tumor growth inhibition (TGI) of 69%, 64%, and 57%, respectively. Displayed time-dependent inhibition of tumor growth.

体内研究

IZCZ-3 (20, 10, and 5 mg/kg; intraperitoneally; every other day for 24 days) inhibits tumor growth in BALB/c nude mice with SiHa human cervical squamous cancer xenograft.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	BALB/c nude mice (5 weeks old) bearing SiHa human cervical squamous cancer xenograft model
Dosage:	20, 10, and 5 mg/kg
Administration:	Treated intraperitoneally; every other day for 24 days
Result:	Treatment with 20, 10, and 5 mg/kg resulted in a significant reduction in tumor weight with tumor growth inhibition (TGI) of 69%, 64%, and 57%, respectively. Displayed time-dependent inhibition of tumor growth.

性状

Solid

溶解性数据

In Vitro:

DMSO : 5 mg/mL (6.98 mM; ultrasonic and warming and heat to 80°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.3968 mL	6.9839 mL	13.9678 mL
5 mM	0.2794 mL	1.3968 mL	2.7936 mL
10 mM	---	---	---

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式