PKC-IN-1|cas:1046787-18-1|西域试剂

PKC-IN-1,98.79%

产品编号：Bellancom-16903| CAS NO：1046787-18-1| 分子式：C₂₅H₃₇FN₈O₂| 分子量：500.61

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
Bellancom-16903	￥2333.00	杭州北京（现货）
Bellancom-16903	￥3500.00	杭州北京（现货）
Bellancom-16903	￥5000.00	杭州北京（现货）
Bellancom-16903	￥15000.00	杭州北京（现货）
Bellancom-16903	￥21000.00	杭州北京（现货）

增值税发票√顺丰快递√订货电话：18601927057

PKC-IN-1

产品介绍

PKC-IN-1 是一种有效的，ATP-竞争性的，可逆的 PKC 抑制剂，对人 PKCβ 和 PKCα 的 K_i 值分别为 5.3 和 10.4 nM，对人 PKCα，PKCβI，PKCβII，PKCθ，PKCγ，PKC mu 和 PKCε 的 IC₅₀ 值分别为 2.3，8.1，7.6，25.6，57.5，314，808 nM。

生物活性

PKC-IN-1 is a potent, ATP-competitive and reversible inhibitor of conventional PKC enzymes with K_is of 5.3 and 10.4 nM for human PKCβ and PKCα, and IC₅₀s of 2.3, 8.1, 7.6, 25.6, 57.5, 314, 808 nM for PKCα, PKCβI, PKCβII, PKCθ, PKCγ, PKC mu and PKCε, respectively.

体外研究

PKC-IN-1 (Compound A) is a potent, ATP-competitive and reversible of conventional PKC enzymes with K_is of 5.3 and 10.4 nM for human PKCβ and PKCα, and IC₅₀s of 2.3, 8.1, 7.6, 25.6, 57.5, 314, 808 nM for PKCα, PKCβI, PKCβII, PKCθ, PKCγ, PKC mu and PKCε, respectively.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

PKC-IN-1 (Compound A; 15 and 30 mg/kg, p.o., bid (twice a day)) dose-dependently and significantly reduces maximum EAE severity and end severity in autoimmune encephalitis (EAE) model in Lewis rats.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

PKC-IN-1 (Compound A; 15 and 30 mg/kg, p.o., bid (twice a day)) dose-dependently and significantly reduces maximum EAE severity and end severity in autoimmune encephalitis (EAE) model in Lewis rats.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : ≥ 25 mg/mL (49.94 mM)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.9976 mL	9.9878 mL	19.9756 mL
5 mM	0.3995 mL	1.9976 mL	3.9951 mL
10 mM	0.1998 mL	0.9988 mL	1.9976 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式