ARL67156 trisodium FPL 67156 trisodium|cas:1021868-83-6|西域试剂

ARL67156 trisodium FPL 67156 trisodium,99.0%

产品编号：Bellancom-103265| CAS NO：1021868-83-6| 分子式：C₁₅H₂₁Br₂N₅Na₃O₁₂P₃| 分子量：785.05

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-103265		￥1800.00	杭州北京（现货）

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ARL67156 trisodium FPL 67156 trisodium

产品介绍

ARL67156 (FPL 67156) trisodium 是一种 ecto-ATPase 抑制剂。ARL67156 trisodium 是竞争性 NTPDase1 (CD39)，NTPDase3 和 NPP1 抑制剂，K_i 分别为 11，18 和 12 μM。ARL67156 trisodium 可用于钙化性主动脉瓣疾病、哮喘等疾病的研究。

生物活性

ARL67156 (FPL 67156) trisodium is a selective ecto-ATPase inhibitor. ARL67156 trisodium is a competitive inhibitor of NTPDase1 (CD39), NTPDase3 and NPP1, with K_is of 11, 18 and 12 μM, respectively. ARL67156 trisodium can be used in the research of calcific aortic valve disease, asthma.

体外研究

ARL67156 trisodium (1-100 μM) potentiates neurogenic contractions in a concentration-dependent manner^[4].
ARL67156 trisodium (10 μg/mL, 24 h) increases the surface expression of CXCR3 on ATP-treated HMC-1 cells^[5].
ARL67156 trisodium (30 μM, 5s) potentiates the norepinephrine release promoted by ATP in guinea pig heart synaptosomes^[6].
ARL67156 trisodium (100 μM, 4h) significantly decreases HIV-1replication in macrophages^[7].

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

ARL67156 trisodium (1.1 μg/kg/day, administered with osmotic pumps implanted subcutaneously, for 28 days) prevents the development of calcific aortic valve disease in Warfarin (HY-B0687)-treated rats.
ARL67156 trisodium (intraperitoneal injection, 2 mg/kg) prevents the increase of serum adenosine concentration induced by Fructose 1,6-bisphosphate (FBP).

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Warfarin-induced mineralization rat model
Dosage:	1.1 μg/kg/day
Administration:	Administered with osmotic pumps implanted subcutaneously, for 28 days
Result:	Prevented the development of aortic stenosis by lowering the level of apoptosis and mineralization of the aortic valve/aorta. Normalized the level of pAkt (an important kinase involved in the survival pathway).

Animal Model:	C57BL/6 mice
Dosage:	2 mg/kg
Administration:	Intraperitoneal injection, 1 h before administration of FBP (100 mg/kg)
Result:	Completely abolished the anti-inflammatory effects of FBP (observed by the neutrophil infiltration, hyperalgesia and oedema of the joint).

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Warfarin-induced mineralization rat model
Dosage:	1.1 μg/kg/day
Administration:	Administered with osmotic pumps implanted subcutaneously, for 28 days
Result:	Prevented the development of aortic stenosis by lowering the level of apoptosis and mineralization of the aortic valve/aorta. Normalized the level of pAkt (an important kinase involved in the survival pathway).

Animal Model:	C57BL/6 mice
Dosage:	2 mg/kg
Administration:	Intraperitoneal injection, 1 h before administration of FBP (100 mg/kg)
Result:	Completely abolished the anti-inflammatory effects of FBP (observed by the neutrophil infiltration, hyperalgesia and oedema of the joint).

性状

Solid

溶解性数据

In Vitro:

H₂O : 25 mg/mL (31.85 mM; Need ultrasonic)

DMSO : 1 mg/mL (1.27 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.2738 mL	6.3690 mL	12.7380 mL
5 mM	0.2548 mL	1.2738 mL	2.5476 mL
10 mM	0.1274 mL	0.6369 mL	1.2738 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

参考文献