RC-3095 TFA|cas:1217463-61-0|西域试剂

RC-3095 TFA,98.03%

产品编号：Bellancom-P0107A| CAS NO：1217463-61-0| 分子式：C₅₈H₈₀F₃N₁₅O₁₁| 分子量：1220.34

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
Bellancom-P0107A	￥4400.00	杭州北京（现货）
Bellancom-P0107A	￥9800.00	杭州北京（现货）
Bellancom-P0107A	￥15500.00	杭州北京（现货）

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RC-3095 TFA

产品介绍

RC-3095 TFA 是一种选择性蛙皮素 (bombesin)/胃泌素 (gastrin) 释放肽受体拮抗剂。RC-3095 TFA 作用于关节炎小鼠，通过减少胃氧化损伤来发挥保护作用。

生物活性

RC-3095 TFA is a selective bombesin/gastrin releasing peptide receptor (GRPR) antagonist. RC-3095 TFA exerts protective effects by reducing gastric oxidative injury in the arthritic mice.

体外研究

体内研究

RC-3095 impairs aversive but not recognition memory in Wistar male rats.
RC-3095 (0.3 mg/kg or 1 mg/kg; S.C.) shows anti-inflammatory effects in 2 experimental models of arthritis, collagen-induced arthritis (CIA) and antigen-induced arthritis (AIA).
Arthritic mice treated with RC-3095 show a significant reduction in the concentrations of IL-17, IL-1 , and TNF, and showed a diminished expression of GRPR.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Balb/c wild-type mice (weighing 18-25 gm) with AIA model; Male DBA/1J inbred mice (weighing 18-25 gm) with CIA model
Dosage:	1 mg/kg for AIA studies; 0.3 mg/kg or 1 mg/kg for CIA studies
Administration:	Injected SC twice a day for a total of 2 or 10 days for AIA studies; Administered SC twice a day for 10 days after the onset of the disease for CIA studies
Result:	Reduced neutrophil migration, mechanical hy pernociception, and proteoglycan loss in mice with AIA; Led to a significant reduction in arthritis clinical scores and the severity of disease in the CIA model.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Balb/c wild-type mice (weighing 18-25 gm) with AIA model; Male DBA/1J inbred mice (weighing 18-25 gm) with CIA model
Dosage:	1 mg/kg for AIA studies; 0.3 mg/kg or 1 mg/kg for CIA studies
Administration:	Injected SC twice a day for a total of 2 or 10 days for AIA studies; Administered SC twice a day for 10 days after the onset of the disease for CIA studies
Result:	Reduced neutrophil migration, mechanical hy pernociception, and proteoglycan loss in mice with AIA; Led to a significant reduction in arthritis clinical scores and the severity of disease in the CIA model.

性状

Solid

溶解性数据

In Vitro:

H₂O : 50 mg/mL (40.97 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	0.8194 mL	4.0972 mL	8.1944 mL
5 mM	0.1639 mL	0.8194 mL	1.6389 mL
10 mM	0.0819 mL	0.4097 mL	0.8194 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture