PDE4B-IN-2|cas:915082-52-9|西域试剂

PDE4B-IN-2,99.21%

产品编号：Bellancom-115687| CAS NO：915082-52-9| 分子式：C₁₉H₁₈ClN₃O₂S| 分子量：387.88

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货号	价格	库存与货期
Bellancom-115687	￥1100.00	杭州北京（现货）
Bellancom-115687	￥1800.00	杭州北京（现货）
Bellancom-115687	￥3600.00	杭州北京（现货）
Bellancom-115687	￥5800.00	杭州北京（现货）
Bellancom-115687	￥9300.00	杭州北京（现货）

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PDE4B-IN-2

产品介绍

PDE4B-IN-2 是一种具有口服活性，选择性 PDE4B 抑制剂，IC₅₀ 为 15 nM。PDE4B-IN-2 抑制 PDE4D (IC₅₀=1.7 µM)。PDE4B-IN-2 表现出有效的抗炎作用。

生物活性

PDE4B-IN-2 is an orally active and selective PDE4B inhibitor with an IC₅₀ of 15 nM. PDE4B-IN-2 inhibits PDE4D (IC₅₀=1.7 µM). PDE4B-IN-2 exhibits potent anti-inflammatory effects.

体外研究

PDE4B-IN-2 (compound 33) does not inhibit CYP1A2, CYP3A4, CYP2C9, and CYP2D (IC₅₀>10 µM).
PDE4B-IN-2 inhibits LPS-induced TNF-aproduction in vitro from mouseperipheral blood mononuclear cell (PBMC; IC₅₀=0.5 M).

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

PDE4B-IN-2 (compound 33; 2 mg/kg; po) has a C_max of 8.7 μg/mL and an AUC of 52.3 μg•h/mL in mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

PDE4B-IN-2 (compound 33; 2 mg/kg; po) has a C_max of 8.7 μg/mL and an AUC of 52.3 μg•h/mL in mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : 25 mg/mL (64.45 mM; ultrasonic and warming and heat to 60°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.5781 mL	12.8906 mL	25.7812 mL
5 mM	0.5156 mL	2.5781 mL	5.1562 mL
10 mM	0.2578 mL	1.2891 mL	2.5781 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式