GDC-0834|cas:1133432-49-1|西域试剂

GDC-0834,98.21%

产品编号：Bellancom-15427| CAS NO：1133432-49-1| 分子式：C₃₃H₃₆N₆O₃S| 分子量：596.74

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货号	价格	库存与货期
Bellancom-15427	￥2333.00	杭州北京（现货）
Bellancom-15427	￥3500.00	杭州北京（现货）
Bellancom-15427	￥5000.00	杭州北京（现货）
Bellancom-15427	￥15000.00	杭州北京（现货）

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GDC-0834

产品介绍

GDC-0834 是一种有效的选择性 BTK 抑制剂。GDC-0834 抑制 BTK，在体外酶实验和细胞实验中，IC₅₀ 分别为 5.9 和 6.4 nM，而在小鼠和大鼠体内，IC₅₀ 分别为 1.1 和 5.6 μM。

生物活性

GDC-0834 is a potent and selective BTK inhibitor. GDC-0834 inhibits BTK with an in vitro IC₅₀ of 5.9 and 6.4 nM in biochemical and cellular assays, respectively, and in vivo IC₅₀ of 1.1 and 5.6 μM in mouse and rat, respectively.

体外研究

GDC-0834 suppresses BTK kinase activity with an IC₅₀ value of 5.9±1.1 nM with Hill slope value of −0.84±0.07 (mean±S.E.). GDC-0834 is shown to be a potent reversible inhibitor of six known aldehyde oxidase (AO) substrates with IC₅₀ values ranging from 0.86 to 1.87 μM.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

The treatment of BALB/c mice with GDC-0834 results in dose-dependent inhibition of pBTK-Tyr223. Animals dosed with 150 or 100 mg/kg GDC-0834 for 2 h show complete inhibition of pBTK-Tyr223 levels in blood, with a mean inhibition of 97 and 96%, respectively. In the rat CIA study, GDC-0834 inhibits pBTK-Tyr223 in rat blood in a dose-dependent manner. The IC₅₀ estimate of pBTK-Tyr223 inhibition in rats is determined to be 5.6±1.6 μM with m of 0.51±0.087 (mean±S.E.).

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : ≥ 32 mg/mL (53.62 mM)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.6758 mL	8.3789 mL	16.7577 mL
5 mM	0.3352 mL	1.6758 mL	3.3515 mL
10 mM	0.1676 mL	0.8379 mL	1.6758 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式