L 888607|cas:860033-06-3|西域试剂

L 888607,99.95%

产品编号：Bellancom-111271| CAS NO：860033-06-3| 分子式：C₁₉H₁₅ClFNO₂S| 分子量：375.84

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
Bellancom-111271	￥3200.00	杭州北京（现货）
Bellancom-111271	￥5200.00	杭州北京（现货）
Bellancom-111271	￥11000.00	杭州北京（现货）
Bellancom-111271	￥17000.00	杭州北京（现货）
Bellancom-111271	￥24000.00	杭州北京（现货）

增值税发票√顺丰快递√订货电话：18601927057

L 888607

产品介绍

L 888607 是一种有效稳定的选择性 CRTH2 激动剂，具有口服活性。L 888607 对人 CRTH2 受体具有高亲和力，K_i 值为 4 nM。L 888607 可用于多种生理事件和代谢的研究。

生物活性

L 888607 is a potent, selective, stable and orally active CRTH2 agonist. L 888607 has high affinity for the human CRTH2 receptor with a K_i value of 4 nM. L 888607 can be used for the research of several physiological events and metabolite.

体外研究

L 888607 has high affinity for the human CRTH2 receptor with a K_i value of 4 nM.
L 888607 has some affinity for the human DP receptor with a K_i value of 211 nM.
L 888607 displays a relatively high selectivity for CRTH2 receptor.
L 888607 has agonistic activity on recombinant and endogenously expressed CRTH2 receptor with an EC₅₀ value of 0.4 nM.
L 888607(100 nM, 20 min) stimulates eosinophil chemotaxis.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Immunofluorescence

Cell Line:	human eosinophils
Concentration:	100 nM
Incubation Time:	20 min
Result:	Significantly stimulated the migration of eosinophils to the bottom chamber.

体内研究
(In Vivo)

L 888607 (i.v., 5 mg/kg, single or oral, 20 mg/kg, single) shows relative stability in vivo.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male (ICR)BR mice
Dosage:	5 mg/kg, 20 mg/kg
Administration:	i.v., 5 mg/kg, single or oral, 20 mg/kg, single
Result:	Showed no obvious side effect.

体内研究

L 888607 (i.v., 5 mg/kg, single or oral, 20 mg/kg, single) shows relative stability in vivo.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male (ICR)BR mice
Dosage:	5 mg/kg, 20 mg/kg
Administration:	i.v., 5 mg/kg, single or oral, 20 mg/kg, single
Result:	Showed no obvious side effect.

体内研究

L 888607 (i.v., 5 mg/kg, single or oral, 20 mg/kg, single) shows relative stability in vivo.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male (ICR)BR mice
Dosage:	5 mg/kg, 20 mg/kg
Administration:	i.v., 5 mg/kg, single or oral, 20 mg/kg, single
Result:	Showed no obvious side effect.

性状

Solid

溶解性数据

In Vitro:

DMSO : ≥ 150 mg/mL (399.11 mM)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.6607 mL	13.3035 mL	26.6071 mL
5 mM	0.5321 mL	2.6607 mL	5.3214 mL
10 mM	0.2661 mL	1.3304 mL	2.6607 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: ≥ 2.5 mg/mL (6.65 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (6.65 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。
将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂： 10% DMSO 90% corn oil
Solubility: ≥ 2.5 mg/mL (6.65 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (6.65 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。