ODN 1668|cas:1186063-66-0|西域试剂

ODN 1668,99.0%

产品编号：Bellancom-150726| CAS NO：1186063-66-0| 分子量：6364.10

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-150726		￥6000.00	杭州北京（现货）
Bellancom-150726		￥15000.00	杭州北京（现货）

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ODN 1668

产品介绍

ODN 1668 是 B 类 CpG ODN (寡脱氧核苷酸)，是一种 TLR-9 激动剂。 ODN 1668 是一种免疫刺激序列，可作为疫苗佐剂。序列：5’-tccatgacgttcctgatgct-3’。

生物活性

ODN 1668, a class B CpG ODN (oligodeoxynucleotide), is a TLR-9 agonist. ODN 1668 is an immunostimulatory sequence and can be used as vaccine adjuvant. Sequence: 5'-tccatgacgttcctgatgct-3’.

体外研究

ODN 1668 induces TNF-α secretion and promotes polyclonal B cell activation.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

ODN 1668 (10 nmol) stimulates responses to protein antigen.
ODN 1668 (1 or 5 mg/kg; i.p. or s.c.; once) causes moderate fever and anorexia in rats.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C57BW6 mice
Dosage:	10 nmol
Administration:	300 μg OVA (ovalbumin) in PBS or liposomes containing OVA were injected with or without 10nmol ODN in the hind footpads of C57BW6 mice. A boost of the same inoculum was given at 2 weeks, and 1 week later blood was taken for serum antibody titering.
Result:	Strongly potentiated the antibody response and induced class switching toward IgG2a and IgG2b. Showed B cell blast formation and a more than twofold increase in B7.2 (CD86) and IL-2 receptor-α (CD25) surface expression.

Animal Model:	Male Wistar rats with body weights in the range of 175–200 g
Dosage:	1 mg/kg or 5 mg/kg
Administration:	Intraperitoneal and subcutaneous injection, once
Result:	Caused moderate fever and anorexia. Induced a significant increase of IL-6. Increased expression of inflammatory genes and activated inflammatory transcription factors.

体内研究

ODN 1668 (10 nmol) stimulates responses to protein antigen.
ODN 1668 (1 or 5 mg/kg; i.p. or s.c.; once) causes moderate fever and anorexia in rats.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C57BW6 mice
Dosage:	10 nmol
Administration:	300 μg OVA (ovalbumin) in PBS or liposomes containing OVA were injected with or without 10nmol ODN in the hind footpads of C57BW6 mice. A boost of the same inoculum was given at 2 weeks, and 1 week later blood was taken for serum antibody titering.
Result:	Strongly potentiated the antibody response and induced class switching toward IgG2a and IgG2b. Showed B cell blast formation and a more than twofold increase in B7.2 (CD86) and IL-2 receptor-α (CD25) surface expression.

Animal Model:	Male Wistar rats with body weights in the range of 175–200 g
Dosage:	1 mg/kg or 5 mg/kg
Administration:	Intraperitoneal and subcutaneous injection, once
Result:	Caused moderate fever and anorexia. Induced a significant increase of IL-6. Increased expression of inflammatory genes and activated inflammatory transcription factors.

性状

Solid

溶解性数据

In Vitro:

H₂O : ≥ 20 mg/mL (3.14 mM)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	0.1571 mL	0.7857 mL	1.5713 mL
5 mM	---	---	---
10 mM	---	---	---

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

参考文献