SP-100030|cas:154563-54-9|西域试剂

SP-100030,99.86%

产品编号：Bellancom-110177| CAS NO：154563-54-9| 分子式：C₁₄H₅ClF₉N₃O| 分子量：437.65

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
Bellancom-110177	￥1400.00	杭州北京（现货）
Bellancom-110177	￥2200.00	杭州北京（现货）
Bellancom-110177	￥5900.00	杭州北京（现货）
Bellancom-110177	￥9200.00	杭州北京（现货）
Bellancom-110177	￥15000.00	杭州北京（现货）

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SP-100030

产品介绍

SP-100030 是一种有效的 NF-κB 和激活蛋白-1 (AP-1) 双抑制剂 (IC₅₀ 分别为 50 和 50 nM)。SP-10003 抑制 Jurkat和其他T细胞系产生的 IL-2、IL-8 和 TNF-α 的产生。SP-100030 降低小鼠胶原性关节炎 (CIA)。

生物活性

SP-100030 is a potent NF-κB and activator protein-1 (AP-1) double inhibitor (IC₅₀s=50 and 50 nM, respectively). SP-100030 inhibits IL-2, IL-8, and TNF-alpha production in Jurkat and other T cell lines. SP-100030 decreases murine collagen-induced arthritis (CIA).

体外研究

SP-100030 blocks the production of IL-2 and IL-8 in Jurkat T-cells at the same concentrations as seen in the luciferase assay (IC₅₀≈30 nM).
ELISA and RT-PCR confirmed that IL-2, IL-8, and TNF-alpha production by activated Jurkat and other T cell lines were inhibited by SP100030.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

SP100030 (10 mg/kg/day; i.p.; day 21 to day 34) significantly decreased arthritis severity.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Six- to 8-wk-old male DBA/1J mice (immunized with type II collagen)
Dosage:	10 mg/kg
Administration:	I.p.; daily, starting at day 21 to the end of the study on day 34
Result:	Significantly decreased arthritis scores compared with controls; Histologic evaluation of the paws from mice treated from day 20 to 34 showed a trend toward decreased inflammation.

体内研究

SP100030 (10 mg/kg/day; i.p.; day 21 to day 34) significantly decreased arthritis severity.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Six- to 8-wk-old male DBA/1J mice (immunized with type II collagen)
Dosage:	10 mg/kg
Administration:	I.p.; daily, starting at day 21 to the end of the study on day 34
Result:	Significantly decreased arthritis scores compared with controls; Histologic evaluation of the paws from mice treated from day 20 to 34 showed a trend toward decreased inflammation.

性状

Solid

溶解性数据

In Vitro:

DMSO : 50 mg/mL (114.25 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.2849 mL	11.4247 mL	22.8493 mL
5 mM	0.4570 mL	2.2849 mL	4.5699 mL
10 mM	0.2285 mL	1.1425 mL	2.2849 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式