CXCR2-IN-1|cas:1873376-49-8|西域试剂

CXCR2-IN-1,99.47%

产品编号：Bellancom-101022| CAS NO：1873376-49-8| 分子式：C₁₉H₂₀Cl₂FN₃O₄S| 分子量：476.35

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
Bellancom-101022	￥3500.00	杭州北京（现货）
Bellancom-101022	￥6000.00	杭州北京（现货）
Bellancom-101022	￥12000.00	杭州北京（现货）
Bellancom-101022	￥19500.00	杭州北京（现货）
Bellancom-101022	￥34000.00	杭州北京（现货）

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CXCR2-IN-1

产品介绍

CXCR2-IN-1是可渗透中枢神经系统的CXCR2拮抗剂，pIC₅₀值为9.3。

生物活性

CXCR2-IN-1 is a central nervous system penetrant CXCR2 antagonist with a pIC₅₀ of 9.3.

体外研究

CXCR2 plays an important role in the activation and recruitment of neutrophils to sites of inflammation. CXCR2-IN-1 (compound 22) shows favorable central nervous system penetration property (Br/Bl>0.45).

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

CXCR2-IN-1 shows efficacy in a cuprizone-induced demyelination model through oral administration, providing evidence to support CXCR2 to be a potential therapeutic target to treat demyelinating diseases such as multiple sclerosis.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : 5.4 mg/mL (11.34 mM; Need ultrasonic and warming)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.0993 mL	10.4965 mL	20.9930 mL
5 mM	0.4199 mL	2.0993 mL	4.1986 mL
10 mM	0.2099 mL	1.0496 mL	2.0993 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式