产品介绍 |
Bromelain 是一种源自菠萝茎的抗炎剂,其通过下调血浆激肽原,抑制前列腺素 E2 表达,降解晚期糖基化终产物受体,调节血管生成生物标志物以及在 COX 途径上游发生抗氧化作用而发挥作用。Bromelain 具有多种纤维蛋白溶解,抗水肿,抗血栓形成和抗炎活性。Bromelain 还具有一些抗癌活性,并促进凋亡细胞死亡。
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生物活性 |
Bromelain is an anti-inflammatory agent derived from pineapple stem that acts through down-regulation of plasma kininogen, inhibition of Prostaglandin E2 expression, degradation of advanced glycation end product receptors and regulation of angiogenic biomarkers as well as antioxidant action upstream in the COX-pathway. Bromelain exhibits various fibrinolytic, antiedematous, antithrombotic, and anti-inflammatory activities. Bromelain also possesses some anticancerous activities and promotes apoptotic cell death.
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体外研究 | |
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体内研究 |
Bromelain (40 mg/kg; intraperitoneal injection; daily; for 7 days; male Sprague-Dawley rats) pretreatment reduces the motor dysfunction in the parkinsonian rat model of parkinson's disease (PD). 6-OHDA injection resulted in marked motor impairment which is prevented by pretreatment with Bromelain prior to the lesion.
西域 has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Model: |
Male Sprague-Dawley rats injected with 6-OHDA |
Dosage: |
40 mg/kg |
Administration: |
Intraperitoneal injection; daily; for 7 days |
Result: |
Reduced the motor dysfunction in the parkinsonian rat model of parkinson's disease (PD).
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体内研究 |
Bromelain (40 mg/kg; intraperitoneal injection; daily; for 7 days; male Sprague-Dawley rats) pretreatment reduces the motor dysfunction in the parkinsonian rat model of parkinson's disease (PD). 6-OHDA injection resulted in marked motor impairment which is prevented by pretreatment with Bromelain prior to the lesion.
西域 has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Model: |
Male Sprague-Dawley rats injected with 6-OHDA |
Dosage: |
40 mg/kg |
Administration: |
Intraperitoneal injection; daily; for 7 days |
Result: |
Reduced the motor dysfunction in the parkinsonian rat model of parkinson's disease (PD).
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性状 | Solid |
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溶解性数据 | |
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运输条件 |
Room temperature in continental US; may vary elsewhere.
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储存方式 |
Powder |
-20°C |
3 years |
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4°C |
2 years |
In solvent |
-80°C |
6 months |
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-20°C |
1 month |
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参考文献 | |
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