OD36|cas:1638644-62-8|西域试剂

OD36,98.70%

产品编号：Bellancom-19628| CAS NO：1638644-62-8| 分子式：C₁₆H₁₅ClN₄O₂| 分子量：330.77

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-19628		￥2500.00	杭州北京（现货）
Bellancom-19628		￥5300.00	杭州北京（现货）

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OD36

产品介绍

OD36 是一种 RIPK2 抑制剂，IC₅₀ 为 5.3 nM。OD36 是一种大环抑制剂，可与 ALK2 激酶 ATP 口袋有效结合。OD36 靶向作用于 ALK2，K_D 为 37 nM。

生物活性

OD36 is a RIPK2 inhibitor with an IC₅₀ of 5.3 nM. OD36 is a macrocyclic inhibitor with potent binding to the ALK2 kinase ATP pocket. OD36 shows ALK2-directed activity with K_Ds of 37 nM.

体外研究

OD36 also inhibits ALK2 and ALK2 R206H with IC₅₀s of 47 and 22 nM, respevtively.
OD36 shows activity against ALK1 with a K_D of 90 nM.
OD36 potently antagonize mutant ALK2 signaling and osteogenic differentiation.
OD36 (0.1-1 μM; 24 h) efficiently inhibits BMP-6 (50 ng/mL)-induced p-Smad1/5 in KS483 cells.
Preincubation of fibrodysplasia ossificans progressiva (FOP) endothelial colony-forming cells (ECFCs) with OD36 (0.5 μM) completely prevents the activation of Smad1/5 and gene targets ID-1 and ID-3 in response to activin A.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis

Cell Line:	KS483 cells
Concentration:	0.1, 0.2, and 1 μM
Incubation Time:
Result:	Inhibited BMP-6 induced p-Smad1/5.

体内研究
(In Vivo)

OD36 (6.25 mg/kg; i.p.; once) alleviates inflammation in an acute peritonitis mice model.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C57BL/6 mice, muramyl dipeptide (MDP)-induced model of peritonitis
Dosage:	6.25 mg/kg
Administration:	Intraperitoneal injection, 30 min prior to MDP
Result:	Inhibited the recruitment of inflammatory cells to the peritoneum, specifically that of neutrophils, and, to a lesser extent, lymphocytes. Decreased RIPK2-specific genes as well as inflammatory cytokine and chemokine gene expression.

体内研究

OD36 (6.25 mg/kg; i.p.; once) alleviates inflammation in an acute peritonitis mice model.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C57BL/6 mice, muramyl dipeptide (MDP)-induced model of peritonitis
Dosage:	6.25 mg/kg
Administration:	Intraperitoneal injection, 30 min prior to MDP
Result:	Inhibited the recruitment of inflammatory cells to the peritoneum, specifically that of neutrophils, and, to a lesser extent, lymphocytes. Decreased RIPK2-specific genes as well as inflammatory cytokine and chemokine gene expression.

体内研究

OD36 (6.25 mg/kg; i.p.; once) alleviates inflammation in an acute peritonitis mice model.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C57BL/6 mice, muramyl dipeptide (MDP)-induced model of peritonitis
Dosage:	6.25 mg/kg
Administration:	Intraperitoneal injection, 30 min prior to MDP
Result:	Inhibited the recruitment of inflammatory cells to the peritoneum, specifically that of neutrophils, and, to a lesser extent, lymphocytes. Decreased RIPK2-specific genes as well as inflammatory cytokine and chemokine gene expression.

性状

Solid

溶解性数据

In Vitro:

DMSO : 33.33 mg/mL (100.76 mM; ultrasonic and warming and heat to 60°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.0232 mL	15.1162 mL	30.2325 mL
5 mM	0.6046 mL	3.0232 mL	6.0465 mL
10 mM	0.3023 mL	1.5116 mL	3.0232 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式