ASK1-IN-1|cas:2411382-24-4|西域试剂

ASK1-IN-1,99.79%

产品编号：Bellancom-133554| CAS NO：2411382-24-4| 分子式：C₁₉H₁₉N₉O₂| 分子量：405.41

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货号	价格	库存与货期
Bellancom-133554	￥2500.00	杭州北京（现货）
Bellancom-133554	￥4500.00	杭州北京（现货）
Bellancom-133554	￥9500.00	杭州北京（现货）
Bellancom-133554	￥15500.00	杭州北京（现货）
Bellancom-133554	￥24500.00	杭州北京（现货）

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ASK1-IN-1

产品介绍

ASK1-IN-1 是一种中枢神经系统渗透剂凋亡信号调节激酶 1 (ASK1) 抑制剂，具有良好的效价 (细胞 IC₅₀=138 nM; Biochemical IC₅₀=21 nM)。

生物活性

ASK1-IN-1 is a CNS-penetrant ASK1 (apoptosis signal-regulating kinase 1) inhibitor, with good potency (cell IC₅₀=138 nM; Biochemical IC₅₀=21 nM).

体外研究

ASK1-IN-1 (compound 21) has superior CYP inhibition profile and it is also inactive in a hERG assay. ASK1-IN-1 is selected for a kinase selectivity profile against a panel of 468 kinases and it is found to be moderately selective.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

ASK1-IN-1 (10 mg/kg; p.o.) covers the cellular IC₅₀/IC₇₀/IC₉₀ at trough in the brain for 12 hours of 50/115/435 mg/kg respectively. ASK1-IN-1 has good biochemical and cellular potency, low clearance and good brain penetration in rodents.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMF : 4 mg/mL (9.87 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Ethanol : < 1 mg/mL (ultrasonic) (insoluble)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.4666 mL	12.3332 mL	24.6664 mL
5 mM	0.4933 mL	2.4666 mL	4.9333 mL
10 mM	---	---	---

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式