L48H37|cas:343307-76-6|西域试剂

L48H37,97.05%

产品编号：Bellancom-126154| CAS NO：343307-76-6| 分子式：C₂₇H₃₃NO₇| 分子量：483.55

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货号	价格	库存与货期
Bellancom-126154	￥800.00	杭州北京（现货）
Bellancom-126154	￥1200.00	杭州北京（现货）
Bellancom-126154	￥2400.00	杭州北京（现货）
Bellancom-126154	￥3800.00	杭州北京（现货）
Bellancom-126154	￥6200.00	杭州北京（现货）

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L48H37

产品介绍

L48H37 是一种化学稳定性提高了的姜黄素 (HY-N0005) 类似物。L48H37 是一种有效且特异性的髓系分化蛋白 2 (MD2) 抑制剂，抑制 LPS-TLR4/MD2 的相互作用和信号转导。L48H37 用于脓毒症或肺损伤的相关研究。

生物活性

L48H37 is an analog of Curcumin (HY-N0005) with improved chemical stability. L48H37 is a potent and specific myeloid differentiation protein 2 (MD2) inhibitor and inhibits the interaction and signaling transduction of LPS-TLR4/MD2. L48H37 is used for the research of sepsis or lung injury treatment.

体外研究

L48H37 inhibits LPS-induced inflammation, particularly TNF-α and IL-6 production and gene expression in mouse macrophages.
L48H37 (0-20 µM; 24 hours) decreases the viability of A549 and H460 cells with IC₅₀ values of 5.3 µM and 2.3 µM, respectively, which is more effective compared to curcumin in lung cancer cells. It shows a low cytotoxicity on normal human lung epithelial cells (BEAS-2B) with IC₅₀ of 21 μM.
L48H37 (1, 2, or 4 µM; 16 hours) dose‐dependently inhibited the expression of p‐Cdc2 and Cdc2, and increases the expression of p53. It also shows increased levels of cleaved poly (ADP‐ribosyl) polymerase (PARP) and reduced levels of anti‐apoptotic protein Bcl‐2 in H460 and A549 cells.
L48H37 (4 µM; 16 hours) rapidly induces intracellular ROS levels dose-dependently as detected by increased DCF levels in H460 and A549 cells.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay

Cell Line:	A549 and H460 cells; BEAS-2B cells
Concentration:	0.625, 1.25, 2.5, 5, 7.5, 10, and 20 µM
Incubation Time:	24 hours
Result:	Inhibited lung cancer cells growth in a concentration-dependent manner.

Western Blot Analysis

Cell Line:	A549 and H460 cells
Concentration:	0.625, 1.25, 2.5, 5, 7.5, 10, and 20 µM
Incubation Time:	24 hours
Result:	Decreased p‐Cdc2, Cdc2, and Bcl‐2 expression in 2 lung cancer cells.

体内研究
(In Vivo)

L48H37 (intraperitoneal injection; 5 mg or 10 mg/kg; once daily; 11‐day ) inhibits H460 xenograft tumor growth and exhibits anti‐tumor activity in mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	5‐week‐old athymic BALB/cA nu/nu female mice (18‐22 g)
Dosage:	5 mg or 10 mg/kg
Administration:	Intraperitoneal injection; once daily; 11‐day
Result:	Reduced tumor wet weights as compared to vehicle control. Decreased the levels of p‐STAT3, and increased the levels of p‐EIF2α and ATF4 in vivo. Exhibited no significant structural changes in mice.

体内研究

L48H37 (intraperitoneal injection; 5 mg or 10 mg/kg; once daily; 11‐day ) inhibits H460 xenograft tumor growth and exhibits anti‐tumor activity in mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	5‐week‐old athymic BALB/cA nu/nu female mice (18‐22 g)
Dosage:	5 mg or 10 mg/kg
Administration:	Intraperitoneal injection; once daily; 11‐day
Result:	Reduced tumor wet weights as compared to vehicle control. Decreased the levels of p‐STAT3, and increased the levels of p‐EIF2α and ATF4 in vivo. Exhibited no significant structural changes in mice.

体内研究

L48H37 (intraperitoneal injection; 5 mg or 10 mg/kg; once daily; 11‐day ) inhibits H460 xenograft tumor growth and exhibits anti‐tumor activity in mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	5‐week‐old athymic BALB/cA nu/nu female mice (18‐22 g)
Dosage:	5 mg or 10 mg/kg
Administration:	Intraperitoneal injection; once daily; 11‐day
Result:	Reduced tumor wet weights as compared to vehicle control. Decreased the levels of p‐STAT3, and increased the levels of p‐EIF2α and ATF4 in vivo. Exhibited no significant structural changes in mice.

性状

Solid

溶解性数据

In Vitro:

DMSO : 50 mg/mL (103.40 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.0680 mL	10.3402 mL	20.6804 mL
5 mM	0.4136 mL	2.0680 mL	4.1361 mL
10 mM	0.2068 mL	1.0340 mL	2.0680 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

参考文献