Pyrrophenone|cas:341973-06-6|西域试剂

Pyrrophenone,99.76%

产品编号：Bellancom-111376| CAS NO：341973-06-6| 分子式：C₄₉H₃₇F₂N₃O₅S₂| 分子量：849.96

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货号	价格	库存与货期
Bellancom-111376	￥2400.00	杭州北京（现货）
Bellancom-111376	￥7500.00	杭州北京（现货）
Bellancom-111376	￥12000.00	杭州北京（现货）

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Pyrrophenone

产品介绍

Pyrrophenone 是一种有效且特异性的胞质磷脂酶 A₂α (cPLA₂α) 抑制剂，IC₅₀ 值为 4.2 nM。

生物活性

Pyrrophenone is a potent and specific cytosolic phospholipase A₂α (cPLA₂α) inhibitor with an IC₅₀ value of 4.2 nM.

体外研究

Pyrrophenone shows potent inhibition of arachidonic acid release, prostaglandin E₂, thromboxane B₂, and leukotriene B₄ formation in human whole blood.
Pyrrophenone inhibits the production of arachidonic acid (AA) (IC₅₀=24±1.7 nM), PGE₂ (IC₅₀=25±19 nM),, and LTC₄ (IC₅₀=14±6.7 nM),from THP-1 cells stimulated with A23187.
Pyrrophenone inhibits the production of AA (IC₅₀=0.19±0.068 μM), PGE₂ (IC₅₀=0.20±0.047 μM), TXB₂ (IC₅₀=0.16±0.093 μM),and LTB₄ (IC₅₀=0.32±0.24 μM) from human whole blood stimulated with A23187.
Pyrrophenone (0.1-0.5 μM, 48 h) inhibits the growth of PC-PTC3 and PCCl₃ cells.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay

Cell Line:	PC-PTC3 and PCCl₃ cells
Concentration:	0.1, 0.3, and 0.5 μM
Incubation Time:	48 hours
Result:	Significantly inhibited basal PC-PTC3 cell proliferation at concentrations as low as 0.1 μM. Basal cell proliferation of normal PCCl₃ cells was also inhibited by 0.5 μM, although to a lesser extent.

体内研究
(In Vivo)

Pyrrophenone (administered i.p. at 20 mg/kg 30 min before LPS injection.) suppresses bronchoalveolar lavage (BAL) levels of leukotriene B4 (LTB₄) and platelet activating factor (PAF).

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Specific pathogen-free female BALB/c mice
Dosage:	20 mg/kg
Administration:	Administered i.p. 30 min before LPS injection
Result:	Suppressed the recruitment of neutrophils and eosinophils, but not macrophages.

体内研究

Pyrrophenone (administered i.p. at 20 mg/kg 30 min before LPS injection.) suppresses bronchoalveolar lavage (BAL) levels of leukotriene B4 (LTB₄) and platelet activating factor (PAF).

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Specific pathogen-free female BALB/c mice
Dosage:	20 mg/kg
Administration:	Administered i.p. 30 min before LPS injection
Result:	Suppressed the recruitment of neutrophils and eosinophils, but not macrophages.

体内研究

Pyrrophenone (administered i.p. at 20 mg/kg 30 min before LPS injection.) suppresses bronchoalveolar lavage (BAL) levels of leukotriene B4 (LTB₄) and platelet activating factor (PAF).

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Specific pathogen-free female BALB/c mice
Dosage:	20 mg/kg
Administration:	Administered i.p. 30 min before LPS injection
Result:	Suppressed the recruitment of neutrophils and eosinophils, but not macrophages.

性状

Solid

溶解性数据

In Vitro:

DMSO : 100 mg/mL (117.65 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.1765 mL	5.8826 mL	11.7653 mL
5 mM	0.2353 mL	1.1765 mL	2.3531 mL
10 mM	0.1177 mL	0.5883 mL	1.1765 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

参考文献