NEP(1-40)|cas:475221-20-6|西域试剂

NEP(1-40),95.67%

产品编号：Bellancom-P1242| CAS NO：475221-20-6| 分子式：C₂₀₆H₃₂₄N₅₆O₆₅| 分子量：4625.11

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货号	价格	库存与货期
Bellancom-P1242	￥4000.00	杭州北京（现货）
Bellancom-P1242	￥13500.00	杭州北京（现货）
Bellancom-P1242	￥21500.00	杭州北京（现货）

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NEP(1-40)

产品介绍

NEP(1-40) 是 Nogo-66 受体 (NgR)的肽类拮抗剂，通过限制髓蛋白抑制逆转损伤引起的小胶质细胞形态分布的改变。

生物活性

NEP(1-40) is a Nogo-66 receptor (NgR) antagonist peptide, reversing the injury-induced shift in distribution of microglia morphologies by limiting myelin-based inhibition.

体外研究

体内研究

NEP(1-40) (89 μg/kg, ip, 15 min and 19 h post-injury) administration further shifts distributions of microglia away from an injury-induced activated morphology towards greater proportions of rod and macrophage-like morphologies.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	74 male Sprague-Dawley rats (328-377 g).
Dosage:	89 μg/kg (97.5% PBS and 2.5% DMSO).
Administration:	IP, 15 min and 19 h post-injury.
Result:	Reduced NgR function immediately post-injury. Increased number of amoeboid microglia/macrophages at 2 days post-injury

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	74 male Sprague-Dawley rats (328-377 g).
Dosage:	89 μg/kg (97.5% PBS and 2.5% DMSO).
Administration:	IP, 15 min and 19 h post-injury.
Result:	Reduced NgR function immediately post-injury. Increased number of amoeboid microglia/macrophages at 2 days post-injury