PLN-1474|cas:2408065-32-5|西域试剂

PLN-1474,99.30%

产品编号：Bellancom-47888| CAS NO：2408065-32-5| 分子式：C₂₄H₃₇N₃O₄| 分子量：431.57

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货号	价格	库存与货期
Bellancom-47888	￥3000.00	杭州北京（现货）
Bellancom-47888	￥4800.00	杭州北京（现货）
Bellancom-47888	￥9500.00	杭州北京（现货）
Bellancom-47888	￥14500.00	杭州北京（现货）

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PLN-1474

产品介绍

PLN-1474 (compound 1) 是具有口服活性的，选择性的 av?1 整合素抑制剂，IC₅₀ 值＜50 nM。PLN-1474 在肝纤维化小鼠模型中显著降低肝脏 pSMAD3/SMAD3 水平、肝脏胶原蛋白基因表达和肝脏 OHP 浓度。PLN-1474 可用于预防、延缓或研究纤维化或肝硬化疾病或紊乱的研究。

生物活性

PLN-1474 (compound 1) is an orally active and selective av?1 integrin inhibitor with an IC₅₀ value of ＜50 nM. PLN-1474 reduces levels of pSMAD3/SMAD3 in liver, hepatic collagen gene expression and hepatic OHP concentration in liver fibrosis mouse model. PLN-1474 can be used for the research of preventing, delaying or researching a fibrotic or cirrhotic disease or disorder.

体外研究

PLN-1474 inhibits ανβ1 and ανβ6 with IC₅₀s of ＜50 nM by solid phase assay.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

PLN-1474 (10 μM) decreases the expression level of profibrotic genes, including COL1A1 and TIMP1 in liver.
PLN-1474 significantly reduces levels of pSMAD3/SMAD3 in liver, hepatic collagen gene expression and hepatic OHP concentration in a mouse model of liver fibrosis.
PLN-1474 (6-12 weeks) prophylactically or therapeutically blocks SMAD3 phosphorylation and significantly decreases OHP levels, collagen gene expression, and collagen deposition examined histologically in the CDAHFD NASH mouse model.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : ≥ 83.33 mg/mL (193.09 mM)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.3171 mL	11.5856 mL	23.1712 mL
5 mM	0.4634 mL	2.3171 mL	4.6342 mL
10 mM	0.2317 mL	1.1586 mL	2.3171 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式