Quinagolide hydrochloride 盐酸喹高利特; CV205-502 hydrochloride|cas:94424-50-7|西域试剂

Quinagolide hydrochloride 盐酸喹高利特; CV205-502 hydrochloride

产品编号：Bellancom-13736A| CAS NO：94424-50-7| 分子式：C₂₀H₃₄ClN₃O₃S| 分子量：432.02

Quinagolide盐酸盐是一种选择性多巴胺D2受体激动剂, 还是一个促乳素抑制剂.

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货号	价格	库存与货期
Bellancom-13736A	￥3500.00	杭州北京（现货）
Bellancom-13736A	￥5000.00	杭州北京（现货）
Bellancom-13736A	￥15000.00	杭州北京（现货）
Bellancom-13736A	￥21000.00	杭州北京（现货）

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Quinagolide hydrochloride 盐酸喹高利特; CV205-502 hydrochloride

产品介绍

Quinagolide hydrochloride (CV205-502 hydrochloride) 是选择性的、具有口服活性的多巴胺 D2 受体 激动剂。Quinagolide hydrochloride 是催乳素抑制剂。Quinagolide hydrochloride 下调 AKT 的水平及其磷酸化。Quinagolide hydrochloride 具有抗肿瘤活性，可用于癌症的研究。

生物活性

Quinagolide hydrochloride (CV205-502 hydrochloride) is a selective and orally active dopamine D2 receptor agonist. Quinagolide hydrochloride is an inhibitor of prolactin. Quinagolide hydrochloride down-regulates AKT levels and its phosphorylation. Quinagolide hydrochloride shows antitumor effects, it can be used for the research of cancer.

体外研究

Quinagolide hydrochloride (100 nM; 48 h) reduces non-ergot dopamine receptor 2 (DRD2) mRNA expression in ectopic lines.
Quinagolide hydrochloride (100 nM; 48 h) inhibits the invasive properties of endometrial mesenchymal stromal cells (E-MSCs).
Quinagolide hydrochloride (100 nM; 24 h) significantly reduces the endothelial differentiation of E-MSCs.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis

Cell Line:	Eutopic and ectopic E-MSCs
Concentration:	100 nM
Incubation Time:	24 h
Result:	Reduced total AKT levels in ectopic E-MSCs and significantly decreased AKT phosphorylation in both eutopic and ectopic cell lines.

体内研究
(In Vivo)

Quinagolide hydrochloride (0.03-0.6 mg/kg; s.c. once daily for 2 month) effectively inhibits tumor growth in vivo.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female Wistar-Furth rats bearing SMtTW tumors
Dosage:	0.03-0.6 mg/kg
Administration:	Subcutaneous injection; 0.03-0.6 mg/kg once daily for 2 month
Result:	Induced normalization of plasma PRL levels in all animals, reduced the tumor size compared with the control group at a dose of 0.3 mg/kg. Showed maximal inhibitory effects on PRL secretion and tumor growth at a dose of 0.3 mg/kg.

体内研究

Quinagolide hydrochloride (0.03-0.6 mg/kg; s.c. once daily for 2 month) effectively inhibits tumor growth in vivo.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female Wistar-Furth rats bearing SMtTW tumors
Dosage:	0.03-0.6 mg/kg
Administration:	Subcutaneous injection; 0.03-0.6 mg/kg once daily for 2 month
Result:	Induced normalization of plasma PRL levels in all animals, reduced the tumor size compared with the control group at a dose of 0.3 mg/kg. Showed maximal inhibitory effects on PRL secretion and tumor growth at a dose of 0.3 mg/kg.

体内研究

Quinagolide hydrochloride (0.03-0.6 mg/kg; s.c. once daily for 2 month) effectively inhibits tumor growth in vivo.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female Wistar-Furth rats bearing SMtTW tumors
Dosage:	0.03-0.6 mg/kg
Administration:	Subcutaneous injection; 0.03-0.6 mg/kg once daily for 2 month
Result:	Induced normalization of plasma PRL levels in all animals, reduced the tumor size compared with the control group at a dose of 0.3 mg/kg. Showed maximal inhibitory effects on PRL secretion and tumor growth at a dose of 0.3 mg/kg.

性状

Solid

溶解性数据

In Vitro:

DMSO : 3.85 mg/mL (8.91 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.3147 mL	11.5735 mL	23.1471 mL
5 mM	0.4629 mL	2.3147 mL	4.6294 mL
10 mM	---	---	---

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

参考文献

. Trouillas J, et al. Inhibitory effects of the dopamine agonists quinagolide (CV 205-502) and bromocriptine on prolactin secretion and growth of SMtTW pituitary tumors in the rat. Endocrinology. 1994 Jan;134(1):401-10. [Content Brief]

. Iampietro C, et al. Quinagolide Treatment Reduces Invasive and Angiogenic Properties of Endometrial Mesenchymal Stromal Cells. Int J Mol Sci. 2022 Feb 4;23(3):1775. [Content Brief]

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Quinagolide hydrochloride 盐酸喹高利特; CV205-502 hydrochloride

Quinagolide hydrochloride 盐酸喹高利特; CV205-502 hydrochloride

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