L-DABA L-2,4-Diaminobutyric acid|cas:1758-80-1|西域试剂

L-DABA L-2,4-Diaminobutyric acid,98.0%

产品编号：Bellancom-101414| CAS NO：1758-80-1| 分子式：C₄H₁₀N₂O₂| 分子量：118.13

L-DABA (L-2,4-Diaminobutyric acid)是GABA转氨酶的弱抑制剂，IC50 值大于500 μM。在体内和体外具有抗肿瘤活性。

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-101414		￥500.00	杭州北京（现货）

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L-DABA L-2,4-Diaminobutyric acid

产品介绍

L-DABA (L-2,4-Diaminobutyric acid)是GABA转氨酶的弱抑制剂，IC₅₀ 值大于500 μM。在体内和体外具有抗肿瘤活性。

生物活性

L-DABA (L-2,4-Diaminobutyric acid) is a week GABA transaminase inhibitor with an IC₅₀ of larger than 500 μM; exhibits antitumor activity in vivo and in vitro.

体外研究

The tumor cells are irreversibly and totally damaged by incubation with 10 mM L-2,4-Diaminobutyric acid for 24 h at 37°C. The cell-destructive effect by L-DABA is probably due to an osmotic lysis induced by the non-saturated intracellular accumulation of L-DABA. The harmful effect of L-DABA could be abolished by concomitant incubation with L-alanine and L-methionine. Kinetic studies indicates that L-DABA is a non-linear, non-competitive inhibitor of GABA transaminase activity. The L-DABA-induced elevation of GABA levels parallels the inhibition of GABA transaminase activity. L-2,4-Diaminobutyric acid, an amino acid analogue, produceS a cytolytic effect with a human glioma cell line, SKMG-1, and normal human fibroblasts. The concentrations of L-DABA necessary to reduce the cell count to 50% of control following a 24-h incubation at 37°C are 12.5 mM for the human fibroblasts and 20 mM for the glioma cell line.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Treatment with L-DABA results in 43.4% reduction of tumor growth. L-DABA is a more effective inhibitor of GABA transaminase in vivo than in vitro.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Treatment with L-DABA results in 43.4% reduction of tumor growth. L-DABA is a more effective inhibitor of GABA transaminase in vivo than in vitro.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

H₂O : 1 mg/mL (8.47 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	8.4653 mL	42.3263 mL	84.6525 mL
5 mM	1.6931 mL	8.4653 mL	16.9305 mL
10 mM	---	---	---

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶