AZD-5672|cas:780750-65-4|西域试剂

AZD-5672,95.0%

产品编号：Bellancom-119101| CAS NO：780750-65-4| 分子式：C₃₂H₃₈F₂N₂O₅S₂| 分子量：632.78

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货号	价格	库存与货期
Bellancom-119101	￥6500.00	杭州北京（现货）
Bellancom-119101	￥10500.00	杭州北京（现货）
Bellancom-119101	￥22500.00	杭州北京（现货）

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AZD-5672

产品介绍

AZD-5672 是一种口服有效的强效选择性 CCR5 拮抗剂 (IC₅₀=0.32 nM)。AZD-5672 对 hERG 离子通道具有中等活性 (结合 IC₅₀=7.3 μM)。AZD5672是人 P-gp 的底物，抑制 P-gp 介导的地高辛转运 (IC₅₀=32 μM)。AZD-5672 可用于类风湿性关节炎的研究。

生物活性

AZD-5672 is an orally active, potent, and selective CCR5 antagonist (IC₅₀=0.32 nM). AZD-5672 shows moderate activity against the hERG ion channel (binding IC₅₀=7.3 μM). AZD5672 is a substrate of human P-gp, and inhibits P-gp-mediated digoxin transport (IC₅₀=32 μM). AZD-5672 can be used for the research of rheumatoid arthritis.

体外研究

AZD-5672 (0, 0.1, 0.3, 1, 3, 10, 30, and 100 μM) inhibits P-gp-mediated digoxin transport in a concentration-dependent manner (mean apparent IC₅₀: 32 μM) in Caco-2 cells.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

In vivo pharmaeokineties data for AZD-5672 (compound 1)

Species	CI^a (mL/min/kg)	V_ss^a (L/kg)	t_1/2^a (h)	F^b (%)
Rat	28	5.3	2.6	38
Dog	18	5.7	3.9	86

^a AZD-5672 dosed 1-2 mg/kg i.v.
^b AZD-5672 dosed 2-5 mg/kg p.o.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

In vivo pharmaeokineties data for AZD-5672 (compound 1)

Species	CI^a (mL/min/kg)	V_ss^a (L/kg)	t_1/2^a (h)	F^b (%)
Rat	28	5.3	2.6	38
Dog	18	5.7	3.9	86

^a AZD-5672 dosed 1-2 mg/kg i.v.
^b AZD-5672 dosed 2-5 mg/kg p.o.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : 33.33 mg/mL (52.67 mM; ultrasonic and warming and heat to 60°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.5803 mL	7.9016 mL	15.8033 mL
5 mM	0.3161 mL	1.5803 mL	3.1607 mL
10 mM	0.1580 mL	0.7902 mL	1.5803 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式