Dovramilast CC-11050|cas:340019-69-4|西域试剂

Dovramilast CC-11050,99.83%

产品编号：Bellancom-147263| CAS NO：340019-69-4| 分子式：C₂₄H₂₈N₂O₆S| 分子量：472.55

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货号	价格	库存与货期
Bellancom-147263	￥3800.00	杭州北京（现货）
Bellancom-147263	￥6000.00	杭州北京（现货）
Bellancom-147263	￥11500.00	杭州北京（现货）

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Dovramilast CC-11050

产品介绍

Dovramilast (CC-11050) 是一种磷酸二酯酶 4 (PDE4) 抑制剂，具有口服活性，可以减少炎症反应，改善 Isoniazid (HY-B0329) 介导的肺部细菌清除。Dovramilast 作为辅助试剂，可用于结核病的研究。

生物活性

Dovramilast (CC-11050) is an orally active phosphodiesterase 4 (PDE4) inhibitor and can reduce the inflammatory response and improves Isoniazid (INH)-mediated bacillary clearance from the lungs. Dovramilast, as an adjunct, is used for the research of tuberculosis (TB).

体外研究

体内研究

Dovramilast (oral gavage, 5, 25, or 50 mg/kg, single) significantly improves antibiotic-mediated bacterial killing and reduces lung pathology.
Pharmacokinetic Parameters of Dovramilast in B6D2F1 mice.

Sampling time(h)		Concentration(ng/ml)
	CC-11050 only		CC-11050+INH
1	1,331.6±136.97		905.35±594.23
2	1,409.47±140.85		1,309.39±214.08
5	948.85±128.7		1,609.18±167.2
8	820.6±265.98		1,271.73±249.18
24	1.27±1.1		4.96±1.85
T_max(h)	2.0		5.0
C_max(ng/ml)	1,410		1,610
AUC_last(ng × h/ml)	10,200		13,900

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	B6D2F1 mice
Dosage:	5, 25, or 50 mg/kg
Administration:	oral, 5, 25, or 50 mg/kg, single
Result:	Reduced PDE4 expression in mtb-infected mouse lungs.

Animal Model:	B6D2F1 mice
Dosage:	5, 25, or 50 mg/kg
Administration:	oral gavage, 5, 25, or 50 mg/kg, single
Result:	Improved antibiotic-mediated bacterial killing and reduced lung pathology.

体内研究

Sampling time(h)		Concentration(ng/ml)
	CC-11050 only		CC-11050+INH
1	1,331.6±136.97		905.35±594.23
2	1,409.47±140.85		1,309.39±214.08
5	948.85±128.7		1,609.18±167.2
8	820.6±265.98		1,271.73±249.18
24	1.27±1.1		4.96±1.85
T_max(h)	2.0		5.0
C_max(ng/ml)	1,410		1,610
AUC_last(ng × h/ml)	10,200		13,900

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	B6D2F1 mice
Dosage:	5, 25, or 50 mg/kg
Administration:	oral, 5, 25, or 50 mg/kg, single
Result:	Reduced PDE4 expression in mtb-infected mouse lungs.

Animal Model:	B6D2F1 mice
Dosage:	5, 25, or 50 mg/kg
Administration:	oral gavage, 5, 25, or 50 mg/kg, single
Result:	Improved antibiotic-mediated bacterial killing and reduced lung pathology.

性状

Solid

溶解性数据

In Vitro:

DMSO : 25 mg/mL (52.90 mM; ultrasonic and warming and heat to 60°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.1162 mL	10.5809 mL	21.1618 mL
5 mM	0.4232 mL	2.1162 mL	4.2324 mL
10 mM	0.2116 mL	1.0581 mL	2.1162 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

参考文献