KP496|cas:217799-03-6|西域试剂

KP496,99.79%

产品编号：Bellancom-U00253| CAS NO：217799-03-6| 分子式：C₃₁H₃₄ClN₃O₇S₃| 分子量：692.27

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-U00253		￥26500.00	杭州北京（现货）

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KP496

产品介绍

KP49是一个有选择性的 Leukotriene D4 and Thromboxane A2 受体的双重拮抗剂。

生物活性

KP496 is a selective, dual antagonist for Leukotriene D4 receptor and Thromboxane A2 receptor.

体外研究

体内研究

KP496 significantly inhibits acute (day 7) and chronic (day 21) lung inflammation. KP496 attenuates the number of lymphocytes on day 7 and those of macrophages, neutrophils, and eosinophils on days 7 and 21. KP496 and prednisolone significantly suppress the increase of hydroxyl-L-proline content in the lung. Compare to respective vehicle control group, the inhibition ratio of KP496 and prednisolone for increase of hydroxyl-L-proline content is about 74 and 63%, respectively. The KP496 (100 mg/head) group and prednisolone (10 mg/kg) group exhibit significant inhibition of numbers of infiltrating total cells, eosinophils, monocytes/macrophages, and lymphocytes compare with the control group. Infiltration of all types of cells except neutrophils is decreased in the KP496 (30m g/head) group, though not to significant extents.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : 200 mg/mL (288.90 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.4445 mL	7.2226 mL	14.4452 mL
5 mM	0.2889 mL	1.4445 mL	2.8890 mL
10 mM	0.1445 mL	0.7223 mL	1.4445 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式