Plecanatide acetate 普卡那肽醋酸盐；醋酸普卡那肽|cas:1075732-84-1|西域试剂

Plecanatide acetate 普卡那肽醋酸盐；醋酸普卡那肽,99.77%

产品编号：Bellancom-108741A| CAS NO：1075732-84-1| 分子式：C₆₇H₁₀₈N₁₈O₂₈S₄| 分子量：1741.94

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-108741A		￥4900.00	杭州北京（现货）
Bellancom-108741A		￥8500.00	杭州北京（现货）

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Plecanatide acetate 普卡那肽醋酸盐；醋酸普卡那肽

产品介绍

Plecanatide acetate 是尿鸟苷蛋白的类似物，是一种具有口服活性的鸟苷酸环化酶 C 受体 (guanylate cyclase-C (GC-C) receptor) 激动剂，在 T84 细胞中，EC₅₀ 值为 190 nM。Plecanatide acetate 可用于慢性特发性便秘的研究，在小鼠结肠炎模型中具有抗炎活性。

生物活性

Plecanatide acetate, an analogue of Uroguanylin, is an orally active guanylate cyclase-C (GC-C) receptor agonist. Plecanatide acetate activates GC-C receptors to stimulate cGMP synthesis with an EC₅₀ of 190 nM in T84 cells assay. Plecanatide acetate can be used for the research of chronic idiopathic constipation, and it also shows anti-inflammatory activity in models of murine colitis.

体外研究

Plecanatide (1 nM-10 μM) activates GC-C receptor to stimulate cGMP synthesis in a dose-dependent manner with EC₅₀ of 190 nM in T84 cells.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Plecanatide (0.5 and 2.5 mg/kg, p.o.) ameliorates spontaneous and chemically induced colitis after treatment for 7 days in BALB/c mice, and 14 days in TCRα^-/- mice.
Plecanatide (0.005-5 mg/kg, once daily for 7 days) also shows anti-inflammatory activity in dextran sulfate sodium (DSS) and trinitrobenzene sulfonic (TNBS)-induced colitis in BDF-1 mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female BALB/c mice (2-4 month old) are induced colitis by TNBS
Dosage:	0, 0.5 and 2.5 mg/kg
Administration:	P.o. for 7 days
Result:	Effectively reduced colitis severity scores as compared to vehicle treatment.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female BALB/c mice (2-4 month old) are induced colitis by TNBS
Dosage:	0, 0.5 and 2.5 mg/kg
Administration:	P.o. for 7 days
Result:	Effectively reduced colitis severity scores as compared to vehicle treatment.