Neocryptotanshinone 新隐丹参酮|cas:109664-02-0|西域试剂

Neocryptotanshinone 新隐丹参酮,98.82%

产品编号：Bellancom-119720| CAS NO：109664-02-0| 分子式：C₁₉H₂₂O₄| 分子量：314.38

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-119720		￥5500.00	杭州北京（现货）
Bellancom-119720		￥9200.00	杭州北京（现货）

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Neocryptotanshinone 新隐丹参酮

产品介绍

Neocryptotanshinone 是从丹参 (Salvia Miltiorrhiza) 分离得到的一种丹参二萜，通过抑制 NF-κB 和 iNOS 信号来抑制脂多糖 (LPS) 诱导的炎症。

生物活性

Neocryptotanshinone, a fatty diterpenoids from Salvia Miltiorrhiza, inhibits lipopolysaccharide-induced inflammation by suppression of NF-κB and iNOS signaling pathways.

体外研究

Neocryptotanshinone exhibits anti-inflammatory effect by suppression of NF-κB and iNOS signaling pathways.
Neocryptotanshinone (10 μM and 20 μM, 24 h) inhibits LPS-induced iNOS protein expression in RAW264.7 cells.
Neocryptotanshinone (20 μM, 24 h) shows no obvious cytotoxic effect towards murine RAW264.7 macrophages.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay

Cell Line:	RAW264.7 cells
Concentration:	5, 10 and 20 μM
Incubation Time:	24 hours
Result:	Inhibited LPS-induced cell viability in a dose-dependent manner.

Western Blot Analysis

Cell Line:	RAW264.7 cells
Concentration:	20 μM
Incubation Time:	24 hours
Result:	Inhibited LPS-induced activation of NF-κB pathway and down-regulated LPS-induced expression of p-NF-κB p65, p-IκBα and p-IKKβ.

体内研究
(In Vivo)

Neocryptotanshinone causes reversals of decreased pain thresholds induced by MSU treatment after 30, 60, and 120 min S. miltiorrhiza Bunge extract treatment (contains single active components).

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	MSU-induced pain model in male ICR mice (weighing 20-25 g)
Dosage:	10, 25, 50 or 100 mg/kg
Administration:	Oral gavage; for 30, 60, 120 min
Result:	Inhibited inflammatory symptoms and nociceptive behaviors in a dose-dependent manner.

体内研究

Neocryptotanshinone causes reversals of decreased pain thresholds induced by MSU treatment after 30, 60, and 120 min S. miltiorrhiza Bunge extract treatment (contains single active components).

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	MSU-induced pain model in male ICR mice (weighing 20-25 g)
Dosage:	10, 25, 50 or 100 mg/kg
Administration:	Oral gavage; for 30, 60, 120 min
Result:	Inhibited inflammatory symptoms and nociceptive behaviors in a dose-dependent manner.

体内研究

Neocryptotanshinone causes reversals of decreased pain thresholds induced by MSU treatment after 30, 60, and 120 min S. miltiorrhiza Bunge extract treatment (contains single active components).

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	MSU-induced pain model in male ICR mice (weighing 20-25 g)
Dosage:	10, 25, 50 or 100 mg/kg
Administration:	Oral gavage; for 30, 60, 120 min
Result:	Inhibited inflammatory symptoms and nociceptive behaviors in a dose-dependent manner.

性状

Solid

溶解性数据

In Vitro:

DMSO : 100 mg/mL (318.09 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.1809 mL	15.9043 mL	31.8086 mL
5 mM	0.6362 mL	3.1809 mL	6.3617 mL
10 mM	0.3181 mL	1.5904 mL	3.1809 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

参考文献