Miravirsen SPC-3649|cas:1072874-90-8|西域试剂

Miravirsen SPC-3649,98.0%

产品编号：Bellancom-132598| CAS NO：1072874-90-8| 分子量：4967.00

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-132598		￥16000.00	杭州北京（现货）

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Miravirsen SPC-3649

产品介绍

Miravirsen (SPC-3649) 是一种有效的 miR-122 抑制剂，抑制 miR-122 的生物生成。Miravirsen 是一种 15 个核苷酸锁定核酸修饰的硫代磷酸反义寡核苷酸。Miravirsen 抑制 HCV 复制。Miravirsen 可用于 HCV 感染的研究。

生物活性

Miravirsen (SPC-3649) is a potent miR-122 inhibitor and inhibits the biogenesis of miR-122. Miravirsen is a 15-nucleotide locked nucleic acid-modified phosphorothioate antisense oligonucleotide. Miravirsen inhibits HCV replication. Miravirsen can be used in research of HCV infection.

体外研究

Miravirsen is thought to work mainly by hybridizing to mature miR-122 and blocking its interaction with HCV RNA, its target sequence is also present in pri- and pre-miR-122.
Miravirsen binds to the stem-loop structure of pri- and pre-miR-122 with nanomolar affinity, and inhibits both Dicer- and Drosha-mediated processing of miR-122 precursors.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Miravirsen (SPC-3649; 2.5-25 mg/kg; i.v.; daily, for 3 d) inhibits miR-122 activity in mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	NMRI female mice (27 g)
Dosage:	2.5, 6.25, 12.5, and 25 mg/kg
Administration:	Intravenous injection; daily, for 3 days
Result:	Inhibited miR-122 activity in a dose-dependent manner.

体内研究

Miravirsen (SPC-3649; 2.5-25 mg/kg; i.v.; daily, for 3 d) inhibits miR-122 activity in mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	NMRI female mice (27 g)
Dosage:	2.5, 6.25, 12.5, and 25 mg/kg
Administration:	Intravenous injection; daily, for 3 days
Result:	Inhibited miR-122 activity in a dose-dependent manner.

性状

Solid

溶解性数据

In Vitro:

H₂O : 100 mg/mL (20.13 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	0.2013 mL	1.0066 mL	2.0133 mL
5 mM	0.0403 mL	0.2013 mL	0.4027 mL
10 mM	0.0201 mL	0.1007 mL	0.2013 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶