Enflicoxib E 6087|cas:251442-94-1|西域试剂

Enflicoxib E 6087,99.90%

产品编号：Bellancom-19384| CAS NO：251442-94-1| 分子式：C₁₆H₁₂F₅N₃O₂S| 分子量：405.34

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
Bellancom-19384	￥2500.00	杭州北京（现货）
Bellancom-19384	￥4000.00	杭州北京（现货）
Bellancom-19384	￥8000.00	杭州北京（现货）
Bellancom-19384	￥12800.00	杭州北京（现货）

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Enflicoxib E 6087

产品介绍

Enflicoxib (E 6087) 是一种非甾体抗炎化合物，可选择性抑制环氧合酶 2 (COX-2)。Enflicoxib 不抑制环氧合酶-1 (COX-1)。E-6087 在动物模型中显示出抗炎、镇痛和解热活性。

生物活性

Enflicoxib (E 6087) is a nonsteroidal anti-inflammatory compound that selectively inhibits cyclooxygenase-2 (COX-2). Enflicoxib does not inhibit cyclooxygenase-1 (COX-1). E-6087 shows anti-inflammatory, analgesic and antipyretic activities in animal models.

体外研究

体内研究

E-6132, one of Enflicoxib (E-6087) metabolites, also inhibits COX-2. After single oral administration of 5 mg/kg of E-6087 to rats, plasma concentrations of Enflicoxib at peak time are higher than those of E-6132, suggesting that activity is mainly due to Enflicoxib.
Enflicoxib (E-6087) is characterized by a long elimination half-life (20-35 h), a low plasma clearance (0.10-0.22 L/h/kg) and a relatively large volume of distribution (2-6 L/kg) in rats and dogs after single oral and intravenous doses. Enflicoxib and E-6132 (a pharmacologically active metabolite) show different pharmacokinetics. The higher percentage of Enflicoxib at early times suggests that Enflicoxib is the main compound responsible for in vivo activity, although E-6132 would contribute to the activity at later times.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male and female Wistar rats (250 g)
Dosage:	5 mg/kg
Administration:	Administered by gastric gavage (10 mL/kg); a single oral dose
Result:	Plasma concentrations of E-6087 at peak time are higher than those of E-6132.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male and female Wistar rats (250 g)
Dosage:	5 mg/kg
Administration:	Administered by gastric gavage (10 mL/kg); a single oral dose
Result:	Plasma concentrations of E-6087 at peak time are higher than those of E-6132.

性状

Solid

溶解性数据

In Vitro:

DMSO : 100 mg/mL (246.71 mM; ultrasonic and warming and heat to 60°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.4671 mL	12.3353 mL	24.6706 mL
5 mM	0.4934 mL	2.4671 mL	4.9341 mL
10 mM	0.2467 mL	1.2335 mL	2.4671 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式