7ß,27-Dihydroxycholesterol 7β, 27-OHC,99.0%
产品编号：Bellancom-138115| CAS NO：240129-43-5| 分子式：C27H46O3| 分子量：418.65
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7ß,27-Dihydroxycholesterol 7β, 27-OHC
| 产品介绍 | 7ß,27-Dihydroxycholesterol (7β, 27-OHC) 是一种强效和选择性的 RORγt 激动剂 (Ki=120 nM)。7ß,27-Dihydroxycholesterol 能够促进小鼠和人的 CD4+ Th17 细胞的分化。7ß,27-Dihydroxycholesterol 也会增加依赖于 CYP27A1 的 IL-17 的产生。 | |||||||||
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| 生物活性 | 7ß,27-Dihydroxycholesterol (7β, 27-OHC) is a potent and selective activator of RORγt (Ki=120 nM). 7ß,27-Dihydroxycholesterol promotes the differentiation of mouse and human CD4+ Th17 cells. 7ß,27-Dihydroxycholesterol also increases the production of IL-17 depended on CYP27A1. | |||||||||
| 体外研究 |
7ß,27-Dihydroxycholesterol (0.3 μM 或 6 μM; 2 h) 在体外分别诱导人类和小鼠 Th17 细胞产生 IL-17。 西域 has not independently confirmed the accuracy of these methods. They are for reference only. | |||||||||
| 体内研究 |
7ß,27-Dihydroxycholesterol (60 mg/kg;皮下注射; 每天 2 次，共 3 天) 在体内诱导小鼠产生 IL-17。 西域 has not independently confirmed the accuracy of these methods. They are for reference only. | |||||||||
| 体内研究 |
7ß,27-Dihydroxycholesterol (60 mg/kg;皮下注射; 每天 2 次，共 3 天) 在体内诱导小鼠产生 IL-17。 西域 has not independently confirmed the accuracy of these methods. They are for reference only. | |||||||||
| 性状 | Solid | |||||||||
| 溶解性数据 | ||||||||||
| 运输条件 | Room temperature in continental US; may vary elsewhere. | |||||||||
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| 参考文献 |
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