Eurycomalactone 东革内酯|cas:23062-24-0|西域试剂

Eurycomalactone 东革内酯,93.24%

产品编号：Bellancom-N4327| CAS NO：23062-24-0| 分子式：C₁₉H₂₄O₆| 分子量：348.39

Eurycomalactone 是一种天然产物，为有效的 NF-κB 抑制剂，IC50 值为 0.5 μM。Eurycomalactone 可抑制蛋白合成，降低 cyclin D1 蛋白水平，但对 TNFα 诱导的 IκBα 降解或 IKKα/β 和 IκBα 的磷酸化水平没有作用。

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	包装	价格	库存与货期	购买量	操作
Bellancom-N4327		￥2100.00	杭州北京（现货）
Bellancom-N4327		￥5200.00	杭州北京（现货）

增值税发票√顺丰快递√订货电话：18601927057

Eurycomalactone 东革内酯

产品介绍

Eurycomalactone 是一种可以从 Eurycoma longifolia Jack 中分离得到的活性拟松类化合物。Eurycomalactone 是一种有效的NF-κB 抑制剂，其 IC₅₀ 值为 0.5 μM。Eurycomalactone 可抑制蛋白合成，降低 cyclin D1 蛋白水平。Eurycomalactone 通过阻滞细胞周期于G2/M 期和延迟 DNA 双链断裂修复来提高放射敏感性。Eurycomalactone 抑制 AKT/NF-κB 信号通路的激活，诱导细胞凋亡并增强对 Cisplatin (HY-17394) 的化疗敏感性。

生物活性

Eurycomalactone is an active quassinoid could be isolated from Eurycoma longifolia Jack. Eurycomalactone is a potent NF-κB inhibitor with an IC₅₀ value of 0.5 μM. Eurycomalactone inhibits protein synthesis and depletes cyclin D1. Eurycomalactone enhances radiosensitivity through arrest cell cycle at G2/M phase and delayed DNA double-strand break repair. Eurycomalactone inhibits the activation of AKT/NF‑κB signaling, induces apoptosis and enhances chemosensitivity to Cisplatin (HY-17394).

体外研究

Eurycomalactone (24, 48 and 72 h) selectively inhibits the viability of A549 and COR-L23 cells Eurycomalactone inhibits the viability of A549 cells with IC₅₀ values of 20.17, 3.77, and 1.90 μM for 24, 48 and 72 hours, respectively. Eurycomalactone inhibits the viability of COR-L23 cells with IC₅₀ values of 25.02, 2.74, and 1.80 μM for 24, 48 and 72 hours, respectively.
Eurycomalactone (2.29-156.3 μM; 24 h; A549 and Calu-1 cells) promotes Non-small cell lung cancer (NSCLC) cells apoptosis.
Eurycomalactone (0-25.05 μM; 24 h; A549 and COR-L23 cells) induces cell cycle arrest at the radiosensitive G2/M phase and induces apoptosis in irradiated Non-small cell lung cancer (NSCLC) cells. Eurycomalactone downregulated the key G2/M regulatory proteins in irradiated Non-small cell lung cancer (NSCLC) cells.
Eurycomalactone (2.5-25 μM; 24 h; A549 cells) suppressed the repair of radiation-Induced DNA double-strand breaks.
Eurycomalactone (2.29-156.3 μM; 24 h; A549 and Calu-1 cells) suppresses AKT/NF-κB activation in Non-small cell lung cancer (NSCLC) cells.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis

Cell Line:	A549 and Calu-1 cells
Concentration:	2.29, 10.14, 12.02, 20.81, 80.77, and 156.3 μM
Incubation Time:	24 hours
Result:	Increased the apoptotic rates in a dose-dependent manner.

Cell Cycle Analysis

Cell Line:	A549 and COR-L23 cells
Concentration:	1.57, 2.57, 20.17 and 25.05 μM
Incubation Time:	24 hours
Result:	Induced cell cycle arrest at G2/M phase in irradiated cells and increased the sub-G1 population. A549 and COR-L23 cells

Western Blot Analysis

Cell Line:	A549 and Calu-1 cells
Concentration:	2.29, 10.14, 12.02, 20.81, 80.77, and 156.3 μM
Incubation Time:	24 hours
Result:	Induced the expression levels of active caspase-3 and active PARP (cleaved form), while decreased Bcl-xL and surviving.

Western Blot Analysis

Cell Line:	A549 and COR-L23 cells
Concentration:	1.57, 2.57, 20.17 and 25.05 μM
Incubation Time:	24 hours
Result:	Downregulated the expression of both G2/M regulatory proteins in a dose-dependent manner.

Western Blot Analysis

Cell Line:	A549 and COR-L23 cells
Concentration:	2.29, 10.14, 12.02, 20.81, 80.77, and 156.3 μM
Incubation Time:	24 hours
Result:	inhibited the expression levels of p^(S473)-AKT, total AKT, p^(S536)-NF-κB p65 and total NF-κB p65.

分子量

348.39

性状

Solid

Formula

C₁₉H₂₄O₆

CAS 号

23062-24-0

中文名称

东革内酯

结构分类

Terpenoids
Diterpenoids

初始来源

Plants
other families

体内研究

性状

Solid

溶解性数据

In Vitro:

DMSO : 100 mg/mL (287.03 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.8703 mL	14.3517 mL	28.7035 mL
5 mM	0.5741 mL	2.8703 mL	5.7407 mL
10 mM	0.2870 mL	1.4352 mL	2.8703 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

参考文献

. Dukaew N, et, al. Enhancement of Radiosensitivity by Eurycomalactone in Human NSCLC Cells Through G₂/M Cell Cycle Arrest and Delayed DNA Double-Strand Break Repair. Oncol Res. 2020 Mar 27;28(2):161-175. [Content Brief]

. Dukaew N, et, al. Inactivation of AKT/NF κB signaling by eurycomalactone decreases human NSCLC cell viability and improves the chemosensitivity to cisplatin. Oncol Rep. 2020 Oct;44(4):1441-1454. [Content Brief]

. Malainer C, et, al. Eurycomalactone Inhibits Expression of Endothelial Adhesion Molecules at a Post-Transcriptional Level. J Nat Prod. 2017 Dec 22;80(12):3186-3193. [Content Brief]

化学品安全说明书(MSDS)

下载MSDS

质检证书(COA)

产品编号(Item Number)

批号(Lot Number)

Eurycomalactone 东革内酯,93.24%

Eurycomalactone 东革内酯

化学品安全说明书(MSDS)

质检证书(COA)

在线咨询