INO5042, a thiazole fused 1,4-naphthoquinone compound, and exhibits anti-inflammation activity.

When INO5042 is added to endothelial cells, a shift of velocities is observed towards fast speeds (from 3-5 to 7-11 microm/sec). The same results is significantly found when neutrophils, alone or along with endothelium, has been submitted to INO5042, the number of stickers and rollers being reduced as well.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

• . Renard M, et al. Induced changes of leukocyte slow rolling in an in flow pharmacological model of adhesion to endothelial cells. Biorheology. 2003;40(1-3):173-8.  [Content Brief]

  . Fosse C, et, al. Parameters and mechanistic studies on the oxidative ring cleavage of synthetic heterocyclic naphthoquinones by Streptomyces strains. Appl Microbiol Biotechnol. 2004 Sep;65(4):446-56.  [Content Brief]