HSR6071|cas:111374-21-1|西域试剂

HSR6071,99.82%

产品编号：Bellancom-U00133| CAS NO：111374-21-1| 分子式：C₁₀H₁₂N₈O| 分子量：260.26

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-U00133		￥3500.00	杭州北京（现货）
Bellancom-U00133		￥5600.00	杭州北京（现货）

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HSR6071

产品介绍

HSR6071 是吡嗪甲酰胺衍生物，是一种具有口服活性的，有效的抗过敏剂。HSR6071 有效抑制大鼠模型的实验性哮喘。

生物活性

HSR6071, a pyrazinecarboxamide derivative, is an orally active and potent antiallergic agent. HSR6071 potently inhibits the experimental asthma in rat models.

体外研究

体内研究

The experimental asthma caused by IgE antibody in rats is inhibited by HSR-6071 (0.01-0.1 mg/kg; i.v.) in a dose-dependent manner. The bronchoconstriction mediated by IgE or IgG antibody in guinea-pigs is also prevented by HSR-6071 (0.3, 1,3 mg/kg; i.v.). HSR-6071 inhibits cyclic AMP phosphodiesterase activity and produces relaxation of the guinea-pig isolated trachea.
HSR-6071 inhibits the IgE-mediated histamine release with an IC₅₀ of 0.46 nM. HSR-6071 is effective not only by i.v. but also by p.o. administration on the IgE mediated PCA in rats. The most potent inhibition with HSR-6071 is observed when it is given p.o. 5 min before the antigen challenge, indicating the rapid absorption of HSR-6071 through the gastrointestinal tract.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

H₂O : 50 mg/mL (192.12 mM; ultrasonic and adjust pH to 12 with NaOH)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.8423 mL	19.2116 mL	38.4231 mL
5 mM	0.7685 mL	3.8423 mL	7.6846 mL
10 mM	0.3842 mL	1.9212 mL	3.8423 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式