BTK inhibitor 10|cas:2241732-30-7|西域试剂

BTK inhibitor 10,99.66%

产品编号：Bellancom-125997| CAS NO：2241732-30-7| 分子式：C₂₅H₂₃N₅O₃| 分子量：441.48

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	包装	价格	库存与货期	购买量	操作
Bellancom-125997		￥5100.00	杭州北京（现货）
Bellancom-125997		￥8200.00	杭州北京（现货）

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BTK inhibitor 10

产品介绍

BTK inhibitor 10 是一种有效的口服活性 Bruton kinase (BTK) 抑制剂，摘自专利 WO2018145525，例 33。BTK inhibitor 10 有潜力用于类风湿关节炎的研究。

生物活性

BTK inhibitor 10 is a potent and orally active Bruton kinase (BTK) inhibitor, extracted from patent WO2018145525, example 33. BTK inhibitor 10 has a potential for rheumatoid arthritis treatment.

体外研究

体内研究

BTK inhibitor 10 (oral gavage; 30 mg/kg; 21 days; once daily) has a significant improvement in arthritis symptoms in CIA mice. The damage of each of the 4 paws in mice is divided into 0-4 to calculate the total score of the limbs. After 21 days’ oral treatment, BTK030 reduces the arthritic score to 3.62 while the control group shows a value of 8.33.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	DBA/1J mice injected with collagen as a CIA model
Dosage:	30 mg/kg
Administration:	oral gavage; 21 days; once daily
Result:	Decreased arthritis scores significantly when it compares to control group.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	DBA/1J mice injected with collagen as a CIA model
Dosage:	30 mg/kg
Administration:	oral gavage; 21 days; once daily
Result:	Decreased arthritis scores significantly when it compares to control group.

性状

Solid

溶解性数据

In Vitro:

DMSO : 50 mg/mL (113.26 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.2651 mL	11.3255 mL	22.6511 mL
5 mM	0.4530 mL	2.2651 mL	4.5302 mL
10 mM	0.2265 mL	1.1326 mL	2.2651 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO 90% corn oil
Solubility: ≥ 2.5 mg/mL (5.66 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (5.66 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。