Ceftobiprole medocaril sodium 头孢比普酯钠盐; BAL5788 sodium|cas:252188-71-9|西域试剂

Ceftobiprole medocaril sodium 头孢比普酯钠盐; BAL5788 sodium,95.70%

产品编号：Bellancom-106574A| CAS NO：252188-71-9| 分子式：C₂₆H₂₅N₈NaO₁₁S₂| 分子量：712.64

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货号	价格	库存与货期
Bellancom-106574A	￥2800.00	杭州北京（现货）
Bellancom-106574A	￥4500.00	杭州北京（现货）
Bellancom-106574A	￥9000.00	杭州北京（现货）
Bellancom-106574A	￥14000.00	杭州北京（现货）

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Ceftobiprole medocaril sodium 头孢比普酯钠盐; BAL5788 sodium

产品介绍

Ceftobiprole medocaril (BAL5788) sodium 是 Ceftobiprole (HY-112579) 的胃肠外前体。Ceftobiprole 是一种非肠道吡咯烷酮头孢菌素。Ceftobiprole 是一种广谱头孢菌素，对甲氧西林 (MRSA) 和耐万古霉素葡萄球菌 (VRSA) 和耐青霉素链球菌具有高水平的体外活性。Ceftobiprole 也抑制革兰氏阳性和革兰氏阴性病原体。

生物活性

Ceftobiprole medocaril (BAL5788) sodium is the parenteral proagent of Ceftobiprole (HY-112579). Ceftobiprole is a parenteral pyrrolidinone cephalosporin. Ceftobiprole is a broad-spectrum cephalosporin with high levels of in vitro activity against methicillin- (MRSA) and vancomycin-resistant staphylococci (VRSA) and penicillin-resistant streptococci. Ceftobiprole also inhibits gram-positive and gram-negative pathogens.

体外研究

体内研究

Ceftobiprole medocaril (s.c.; 3 × q12h; total daily doses of BAL9141 equivalents, 2.1, 4.2, or 8.4 mg/kg) causes ten-day cumulative survival rates ranged from 57 to 100% for female Swiss albino mice (body weight, 20 to 22 g) infected Pen^r Cro^s Ctx^s strain P-15986.
Ceftobiprole medocaril (10, 40, 160 mg/kg; single dose; sc) has T_1/2s from 20 min to 31 min, as the dose rose from 40 mg/kg to 160 mg/kg. The AUC/dose values for the escalating single doses ranges from 0.585 to 1.33, and the C_max/dose values decreases from 1.08 to 0.90 in neutropenic thigh-infected mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : 250 mg/mL (350.81 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.4032 mL	7.0162 mL	14.0323 mL
5 mM	0.2806 mL	1.4032 mL	2.8065 mL
10 mM	0.1403 mL	0.7016 mL	1.4032 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

参考文献