Ordesekimab AMG 714; PRV-015
产品编号：Bellancom-P99410| CAS NO：879293-15-9
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Ordesekimab AMG 714; PRV-015
| 产品介绍 | Ordesekimab (AMG 714; PRV-015)是一种人 IgG1κ 抗 IL-15 (Interleukin Related) 单克隆抗体。Ordesekimab 与 IL-15 的结合抑制 IL-15 与 IL-2Rβ 和 IL-15 受体复合物的共同 γ 链的相互作用，但不与 IL-15Rα 链相互作用。Ordesekimab 具有研究无反应性乳糜泻 (NRCD) 的潜力。 |
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| 生物活性 | Ordesekimab (AMG 714; PRV-015) is a fully human IgG1κ anti-IL-15 (Interleukin Related) monoclonal antibody. The binding of Ordesekimab to IL-15 inhibits the interaction of IL-15 with the IL-2Rβ and common γ chain of the IL-15 receptor complex, but not with the IL-15Rα chain. Ordesekimab has the potential for study of nonresponsive celiac disease (NRCD). |
| 体外研究 |
The simultaneous binding of Ordesekimab (AMG 714) to the Fcγ receptor (R) IIIα expressed on natural killer (NK) cells and to the IL-15/IL-15Rα complex on cells such as monocytes may theoretically enable antibody-dependent cell-mediated cytotoxicity (ADCC) toward the IL-15Rα-expressing cells. 西域 has not independently confirmed the accuracy of these methods. They are for reference only. |
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| 储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
| 参考文献 |
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