Oxelumab R 4930; huMAb OX 40L; Ro 49-89991|cas:1186098-83-8|西域试剂

Oxelumab R 4930; huMAb OX 40L; Ro 49-89991,95.0%

产品编号：Bellancom-P99408| CAS NO：1186098-83-8

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货号	价格	库存与货期
Bellancom-P99408	￥3500.00	杭州北京（现货）
Bellancom-P99408	￥9000.00	杭州北京（现货）
Bellancom-P99408	￥14400.00	杭州北京（现货）

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产品介绍

Oxelumab (R 4930) 是一种靶向 OX40 配体 (OX40L) 的人单克隆抗体。Oxelumab 可用于哮喘的研究。

生物活性

Oxelumab (R 4930) is a human monoclonal antibody against the OX40 ligand (OX40L). Oxelumab can be used for the research of asthma.

体外研究

Oxelumab (10 μg/mL；3 天) 抑制 NK 细胞的增殖.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay

Cell Line:	Natural Killer (NK) cell lines
Concentration:	10 μg/mL
Incubation Time:	3 days
Result:	Inhibited cell proliferation of NK cells.

体内研究
(In Vivo)

Oxelumab (5 和 30 mg/kg；腹腔注射，每天一次，共两次) 影响 IL-6 的浓度和脾人效应记忆 T 细胞和开关 B 细胞的频率。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	NSG mice with PBMCs from UC patients with simple clinical colitis activity index (SCCAI)
Dosage:	5 and 30 mg/kg
Administration:	Intraperitoneal injectionon; 5 and 30 mg/kg, once daily, on days 6 and 13
Result:	Reversed the ethanol-induced colon dilated and the lost of distinct pattern of pellets. Decreased the level of IL-6 and increased the concentrations of glutamic acid. Reduced frequencies of splenic human effector memory T cells and switched B cells.

体内研究

Oxelumab (5 和 30 mg/kg；腹腔注射，每天一次，共两次) 影响 IL-6 的浓度和脾人效应记忆 T 细胞和开关 B 细胞的频率。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	NSG mice with PBMCs from UC patients with simple clinical colitis activity index (SCCAI)
Dosage:	5 and 30 mg/kg
Administration:	Intraperitoneal injectionon; 5 and 30 mg/kg, once daily, on days 6 and 13
Result:	Reversed the ethanol-induced colon dilated and the lost of distinct pattern of pellets. Decreased the level of IL-6 and increased the concentrations of glutamic acid. Reduced frequencies of splenic human effector memory T cells and switched B cells.

体内研究

Oxelumab (5 和 30 mg/kg；腹腔注射，每天一次，共两次) 影响 IL-6 的浓度和脾人效应记忆 T 细胞和开关 B 细胞的频率。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	NSG mice with PBMCs from UC patients with simple clinical colitis activity index (SCCAI)
Dosage:	5 and 30 mg/kg
Administration:	Intraperitoneal injectionon; 5 and 30 mg/kg, once daily, on days 6 and 13
Result:	Reversed the ethanol-induced colon dilated and the lost of distinct pattern of pellets. Decreased the level of IL-6 and increased the concentrations of glutamic acid. Reduced frequencies of splenic human effector memory T cells and switched B cells.