CP681301|cas:865317-32-4|西域试剂

CP681301,99.18%

产品编号：Bellancom-150082| CAS NO：865317-32-4| 分子式：C₁₇H₂₂N₄O| 分子量：298.38

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货号	价格	库存与货期
Bellancom-150082	￥1500.00	杭州北京（现货）
Bellancom-150082	￥2500.00	杭州北京（现货）
Bellancom-150082	￥5500.00	杭州北京（现货）
Bellancom-150082	￥8500.00	杭州北京（现货）
Bellancom-150082	￥13500.00	杭州北京（现货）

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CP681301

产品介绍

CP681301 是一种有效的 CDK5 抑制剂。CP681301 显示出抗增殖活性。CP681301 降低 GSC 中 CD133、OLIG2、SOX2、KI67、pCDK5 蛋白水平的表达。CP681301 减少小鼠胶质瘤异种移植物的自我更新。CP681301 在果蝇中显示出抗肿瘤活性。

生物活性

CP681301 is a potent CDK5 inhibitor. CP681301 shows antiproliferative activity. CP681301 decreases the expression of CD133, OLIG2, SOX2, KI67, pCDK5 protein level in GSCs (Glioma stem cells). CP681301 reduces self-renewal in mouse glioma xenografts. CP681301 shows anti-tumor activity in Drosophila.

体外研究

CP681301 (1 µM; 96 h) shows variably cytotoxic to the tested GSC cultures but is not toxic to NHNPs.
CP681301 (0, 10, 50 µM; 48 h) decreases the expression of CD133, OLIG2, SOX2, KI67, pCDK5 protein level in GSCs.
CP681301 (0, 0.5, 1 µM; ) suppresses the expression of CREB Ser133 phosphorylation.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay

Cell Line:	NHNP, N12.159, GBM121, GBM39, N08-74 cells
Concentration:	1 µM
Incubation Time:	96 h
Result:	Showed variably cytotoxic to the tested GSC cultures but was not toxic to NHNPs (normal human neuro-progenitors).

Western Blot Analysis

Cell Line:	GBM 121, GBM39 cells
Concentration:	1 µM
Incubation Time:	48 h
Result:	Suppressed the expression of CD133, OLIG2, and SOX2 and cell proliferation marker KI67.

体内研究
(In Vivo)

CP681301 (1 mM; fed; 10 days) shows anti-tumor activity in 0- to 2-day-old adult Drosophila.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	0- to 2-day-old adult Drosophila (brat-RNAi tumors)
Dosage:	1 mM
Administration:	Fed, 10 days
Result:	Reduced active phospho-dCdk5 (Y15) in tumor cells and the self-renewal properties of stem cells, increased the expression of neuronal marker ElaV in these cells and increased the median survival by 2.8-fold.

体内研究

CP681301 (1 mM; fed; 10 days) shows anti-tumor activity in 0- to 2-day-old adult Drosophila.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	0- to 2-day-old adult Drosophila (brat-RNAi tumors)
Dosage:	1 mM
Administration:	Fed, 10 days
Result:	Reduced active phospho-dCdk5 (Y15) in tumor cells and the self-renewal properties of stem cells, increased the expression of neuronal marker ElaV in these cells and increased the median survival by 2.8-fold.

体内研究

CP681301 (1 mM; fed; 10 days) shows anti-tumor activity in 0- to 2-day-old adult Drosophila.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	0- to 2-day-old adult Drosophila (brat-RNAi tumors)
Dosage:	1 mM
Administration:	Fed, 10 days
Result:	Reduced active phospho-dCdk5 (Y15) in tumor cells and the self-renewal properties of stem cells, increased the expression of neuronal marker ElaV in these cells and increased the median survival by 2.8-fold.

性状

Solid

溶解性数据

In Vitro:

DMSO : ≥ 100 mg/mL (335.14 mM)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.3514 mL	16.7572 mL	33.5143 mL
5 mM	0.6703 mL	3.3514 mL	6.7029 mL
10 mM	0.3351 mL	1.6757 mL	3.3514 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

参考文献