Sodium zirconium cyclosilicate is an orally administered, non-absorbed, novel, inorganic microporous zirconium silicate compound, is a highly selective cation exchanger that selectively removes excess K⁺ in vivo. Sodium zirconium cyclosilicate can be used in research of chronic kidney disease (CKD).

Sodium zirconium cyclosilicate (ZS-9) is an inorganic cation exchange crystalline compound that has a high capacity to selectively entrap monovalent cations, specifically excess K⁺ and ammonium ions. Sodium zirconium cyclosilicate has the exchange capacities for the divalent ions Ca²⁺ and Mg²⁺ are below 0.05 mEq/g, and a >25-fold selectivity for K⁺ over either Ca²⁺ or Mg²⁺.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Sodium zirconium cyclosilicate (ZS-9; 2-6 g/kg; p.o.; daily, for 5 d) is a recovery in feces of Sprague-Dawley rats and can efficient uptake and removal of potassium ions.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Sodium zirconium cyclosilicate (ZS-9; 2-6 g/kg; p.o.; daily, for 5 d) is a recovery in feces of Sprague-Dawley rats and can efficient uptake and removal of potassium ions.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

• . Stavros F, et, al. Characterization of structure and function of ZS-9, a K+ selective ion trap. PLoS One. 2014 Dec 22;9(12):e114686.  [Content Brief]

  . Ash SR, et, al. A phase 2 study on the treatment of hyperkalemia in patients with chronic kidney disease suggests that the selective potassium trap, ZS-9, is safe and efficient. Kidney Int. 2015 Aug;88(2):404-11.  [Content Brief]