Procaterol hydrochloride hemihydrate OPC 2009 hydrochloride hemihydrate|cas:81262-93-3|西域试剂

Procaterol hydrochloride hemihydrate OPC 2009 hydrochloride hemihydrate,99.88%

产品编号：Bellancom-129041| CAS NO：81262-93-3| 分子式：C₁₆H₂₃ClN₂O₃.1/2H₂O| 分子量：335.82

盐酸丙卡特罗半水合物是一种口服活性β2肾上腺素受体激动剂。盐酸丙卡特罗半水合物可用于哮喘的研究。

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货号	价格	库存与货期
Bellancom-129041	￥1500.00	杭州北京（现货）
Bellancom-129041	￥2200.00	杭州北京（现货）
Bellancom-129041	￥3900.00	杭州北京（现货）
Bellancom-129041	￥6500.00	杭州北京（现货）

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Procaterol hydrochloride hemihydrate OPC 2009 hydrochloride hemihydrate

产品介绍

Procaterol hydrochloride hemihydrate 是一种具有口服活性的 β2 肾上腺素受体 (β2 adrenoreceptor) 激动剂。Procaterol hydrochloride hemihydrate 可用于哮喘研究。

生物活性

Procaterol hydrochloride hemihydrate is an orally active β2 adrenoreceptor agonist. Procaterol hydrochloride hemihydrate can be used for the research of asthma.

体外研究

Procaterol hydrochloride hemihydrate (0.1 μM，24-72 小时) 抑制人气管上皮细胞中的鼻病毒感染^[4]。
Procaterol hydrochloride hemihydrate (0-1 μg/mL, 24/48 h) 抑制 BEAS-2B 细胞中 IL-1β- 和 TNF-α 介导的嗜酸性粒细胞趋化活性^[5]。
Procaterol hydrochloride hemihydrate (25-200 nM, 20 h) 保护 16HBE 细胞免受 H₂O₂ 诱导的氧化应激^[6]。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Procaterol hydrochloride hemihydrate (1、3 或 10 μg/mL，吸入给药) 抑制过敏性炎症豚鼠气道中组胺引起的气流阻塞和微血管渗漏。
Procaterol hydrochloride hemihydrate (0.1 mg/kg，i.p.) 完全消除有意识的豚鼠中 Mch 引起的咳嗽。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Allergic inflammatory guinea-pig model
Dosage:	1, 3 or 10 μg/mL
Administration:	Inhaled administration
Result:	Inhibited histamine-induced airflow obstruction and microvascular leakage.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Allergic inflammatory guinea-pig model
Dosage:	1, 3 or 10 μg/mL
Administration:	Inhaled administration
Result:	Inhibited histamine-induced airflow obstruction and microvascular leakage.

性状

Solid

溶解性数据

In Vitro:

H₂O : 25 mg/mL (74.44 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.9778 mL	14.8889 mL	29.7779 mL
5 mM	0.5956 mL	2.9778 mL	5.9556 mL
10 mM	0.2978 mL	1.4889 mL	2.9778 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

参考文献

. Tukiainen H, et al. Comparison between oral procaterol and salbutamol in patients with bronchial asthma. Curr Med Res Opin. 1988;11(4):236-41. [Content Brief]

. Mirza ZN, et al. Inhaled procaterol inhibits histamine-induced airflow obstruction and microvascular leakage in guinea-pig airways with allergic inflammation. Clin Exp Allergy. 1998 May;28(5):644-52. [Content Brief]

. Ohkura N, et al. Bronchoconstriction-triggered cough in conscious guinea pigs. Exp Lung Res. 2009 May;35(4):296-306. [Content Brief]

[4]. Yamaya M, et al. Procaterol inhibits rhinovirus infection in primary cultures of human tracheal epithelial cells. Eur J Pharmacol. 2011 Jan 10;650(1):431-44. [Content Brief]

[5]. Koyama S, et al. Procaterol inhibits IL-1beta- and TNF-alpha-mediated epithelial cell eosinophil chemotactic activity. Eur Respir J. 1999 Oct;14(4):767-75. [Content Brief]

[6]. Deng Z, et al. Procaterol but not dexamethasone protects 16HBE cells from H₂O₂-induced oxidative stress. J Pharmacol Sci. 2014;125(1):39-50. [Content Brief]

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Procaterol hydrochloride hemihydrate OPC 2009 hydrochloride hemihydrate,99.88%

Procaterol hydrochloride hemihydrate OPC 2009 hydrochloride hemihydrate

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