ESI-08|cas:301177-43-5|西域试剂

ESI-08,99.25%

产品编号：Bellancom-136172| CAS NO：301177-43-5| 分子式：C₂₀H₂₃N₃OS| 分子量：353.48

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货号	价格	库存与货期
Bellancom-136172	￥1350.00	杭州北京（现货）
Bellancom-136172	￥2250.00	杭州北京（现货）
Bellancom-136172	￥4950.00	杭州北京（现货）
Bellancom-136172	￥7650.00	杭州北京（现货）
Bellancom-136172	￥12150.00	杭州北京（现货）

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ESI-08

产品介绍

ESI-08 是一种有效的选择性 EPAC 拮抗剂，可以完全抑制 EPAC1 和 EPAC2 (IC₅₀ 为 8.4 μM) 的活性。ESI-08 选择性阻断 cAMP 诱导的 EPAC 激活，但不抑制 cAMP 介导的 PKA 激活。

生物活性

ESI-08 is a potent and selective EPAC antagonist, which can completely inhibit both EPAC1 and EPAC2 (IC₅₀ of 8.4 μM) activity. ESI-08 selectively blocks cAMP-induced EPAC activation, but does not inhibit cAMP-mediated PKA activation.

体外研究

Exchange proteins directly activated by cAMP (EPAC) are a family of guanine nucleotide exchange factors that regulate a wide variety of intracellular processes in response to second messenger cAMP. ESI-08 at 25 μM has been found not to alter cAMP-induced type I and II PKA holoenzymes activation while H89, a selective PKA inhibitor, blocked the type I or II PKA activities completely.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

性状

Solid

溶解性数据

In Vitro:

DMSO : 100 mg/mL (282.90 mM; ultrasonic and warming and heat to 60°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.8290 mL	14.1451 mL	28.2901 mL
5 mM	0.5658 mL	2.8290 mL	5.6580 mL
10 mM	0.2829 mL	1.4145 mL	2.8290 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

参考文献