Bisindolylmaleimide XI hydrochloride Ro 32-0432; Ro 31-8830 hydrochloride,98.0%
产品编号:Bellancom-117610A| CAS NO:145333-02-4| 分子式:C28H29ClN4O2| 分子量:489.01
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Bisindolylmaleimide XI hydrochloride Ro 32-0432; Ro 31-8830 hydrochloride
产品介绍 | Bisindolylmaleimide XI hydrochloride (Ro 32-0432) 是一种有效、选择性和具有口服活性的 PKC 抑制剂,对 PKCα、PKCβI、PKCβII、PKCγ 的 IC50 分别为 9 nM、28 nM、31 nM、37 nM 和 108 nM。 |
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生物活性 | Bisindolylmaleimide XI hydrochloride (Ro 32-0432) is a potent, selective and orally active PKC inhibitor with IC50s of 9 nM, 28 nM, 31 nM, 37 nM, and 108 nM for PKCα, PKCβI, PKCβII, PKCγ, and PKCε, respectively. |
体外研究 |
Bisindolylmaleimide XI hydrochloride (Ro 32-0432) inhibits IL-2 secretion, IL-2 receptor expression in, and proliferation of, peripheral human T-cells stimulated with phorbol ester together with phytohemagglutin or anti-CD3, but does not inhibit IL-2 induced proliferation in cells already stimulated to express IL-2 receptors. Proliferation of the influenza peptide antigen HA 307-319-specific human T-cell clone (HA27) after exposure to antigen-pulsed autologous presenting cells is also inhibited by Bisindolylmaleimide XI hydrochloride. 西域 has not independently confirmed the accuracy of these methods. They are for reference only. |
体内研究 |
Oral administration of Bisindolylmaleimide XI hydrochloride inhibits subsequent phorbol ester-induced edema in ratss. Induction of more physiologically T-cell driven responses such as host vs. graft responses and the secondary paw swelling in adjuvant-induced arthritis are also inhibited by Bisindolylmaleimide XI hydrochloride. 西域 has not independently confirmed the accuracy of these methods. They are for reference only. |
体内研究 |
Oral administration of Bisindolylmaleimide XI hydrochloride inhibits subsequent phorbol ester-induced edema in ratss. Induction of more physiologically T-cell driven responses such as host vs. graft responses and the secondary paw swelling in adjuvant-induced arthritis are also inhibited by Bisindolylmaleimide XI hydrochloride. 西域 has not independently confirmed the accuracy of these methods. They are for reference only. |
性状 | Solid |
溶解性数据 | |
运输条件 | Room temperature in continental US; may vary elsewhere. |
储存方式 |
-20°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
参考文献 |
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