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Bisindolylmaleimide XI hydrochloride Ro 32-0432; Ro 31-8830 hydrochloride,98.0%

产品编号:Bellancom-117610A| CAS NO:145333-02-4| 分子式:C28H29ClN4O2| 分子量:489.01

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货号 包装 价格 库存与货期 购买量 操作
Bellancom-117610A
3000.00 杭州 北京(现货)

增值税发票√顺丰快递√订货电话:18601927057

Bisindolylmaleimide XI hydrochloride Ro 32-0432; Ro 31-8830 hydrochloride

产品介绍 Bisindolylmaleimide XI hydrochloride (Ro 32-0432) 是一种有效、选择性和具有口服活性的 PKC 抑制剂,对 PKCαPKCβIPKCβIIPKCγIC50 分别为 9 nM、28 nM、31 nM、37 nM 和 108 nM。
生物活性

Bisindolylmaleimide XI hydrochloride (Ro 32-0432) is a potent, selective and orally active PKC inhibitor with IC50s of 9 nM, 28 nM, 31 nM, 37 nM, and 108 nM for PKCα, PKCβI, PKCβII, PKCγ, and PKCε, respectively.

体外研究

Bisindolylmaleimide XI hydrochloride (Ro 32-0432) inhibits IL-2 secretion, IL-2 receptor expression in, and proliferation of, peripheral human T-cells stimulated with phorbol ester together with phytohemagglutin or anti-CD3, but does not inhibit IL-2 induced proliferation in cells already stimulated to express IL-2 receptors. Proliferation of the influenza peptide antigen HA 307-319-specific human T-cell clone (HA27) after exposure to antigen-pulsed autologous presenting cells is also inhibited by Bisindolylmaleimide XI hydrochloride.
PKC inhibition with Bisindolylmaleimide XI hydrochloride (Ro 32-0432; 1 μM) decreases the proportion of apoptotic cells (-21%) in retinal progenitor cells (RPCs).

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Oral administration of Bisindolylmaleimide XI hydrochloride inhibits subsequent phorbol ester-induced edema in ratss. Induction of more physiologically T-cell driven responses such as host vs. graft responses and the secondary paw swelling in adjuvant-induced arthritis are also inhibited by Bisindolylmaleimide XI hydrochloride.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Oral administration of Bisindolylmaleimide XI hydrochloride inhibits subsequent phorbol ester-induced edema in ratss. Induction of more physiologically T-cell driven responses such as host vs. graft responses and the secondary paw swelling in adjuvant-induced arthritis are also inhibited by Bisindolylmaleimide XI hydrochloride.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状Solid
溶解性数据
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

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