STING agonist-12|cas:2259624-71-8|西域试剂

STING agonist-12,98.63%

产品编号：Bellancom-147010| CAS NO：2259624-71-8| 分子式：C₂₅H₁₉ClF₄N₂O₂| 分子量：490.88

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货号	价格	库存与货期
Bellancom-147010	￥3800.00	杭州北京（现货）
Bellancom-147010	￥6200.00	杭州北京（现货）
Bellancom-147010	￥12500.00	杭州北京（现货）

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STING agonist-12

产品介绍

STING agonist-12 (Compound 53) 是一种口服有效的人 STING 激活剂，EC₅₀ 为 185 nM。

生物活性

STING agonist-12 (Compound 53) is a potent, orally active human STING activator with an EC₅₀ of 185 nM.

体外研究

STING agonist-12 (Compound 53) (10 μM) shows excellent pan-polymorph activity across the panel of STING proteins (92%, 107% and 92% against R232, H232 and HAQ, respectively) in HEK293T cells.
STING agonist-12 is not active at mouse STING.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

STING agonist-12 (Compound 53) (5 mpk for i.v.; 10 mpk for p.o.) is well-absorbed with a short terminal half-life.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Balb/c mice (n=3)

Dosage:

5 or 10 mpk

Administration:

Lateral tail vein or oral gavage (Pharmacokinetic Analysis)

Result:

Pharmacokinetic profile of STING agonist-12 (Compound 53) in mouse.

Route	DOSE (mpk)	AUC (ng/mL*h)	T_1/2 (h)	C_max (ng/mL)	V_d (mL/kg)	F (%)
IV	5	1215	1.41	1867	2689	NA
PO	10	2090	NA	1723	NA	86

体内研究

STING agonist-12 (Compound 53) (5 mpk for i.v.; 10 mpk for p.o.) is well-absorbed with a short terminal half-life.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Balb/c mice (n=3)

Dosage:

5 or 10 mpk

Administration:

Lateral tail vein or oral gavage (Pharmacokinetic Analysis)

Result:

Pharmacokinetic profile of STING agonist-12 (Compound 53) in mouse.

Route	DOSE (mpk)	AUC (ng/mL*h)	T_1/2 (h)	C_max (ng/mL)	V_d (mL/kg)	F (%)
IV	5	1215	1.41	1867	2689	NA
PO	10	2090	NA	1723	NA	86

性状

Solid

溶解性数据

In Vitro:

DMSO : 250 mg/mL (509.29 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.0372 mL	10.1858 mL	20.3716 mL
5 mM	0.4074 mL	2.0372 mL	4.0743 mL
10 mM	0.2037 mL	1.0186 mL	2.0372 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

参考文献