Mongersen GED-0301|cas:1443994-46-4|西域试剂

Mongersen GED-0301,95.25%

产品编号：Bellancom-145721| CAS NO：1443994-46-4| 分子量：6584.00

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-145721		￥8500.00	杭州北京（现货）

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Mongersen GED-0301

产品介绍

Mongersen (GED-0301) 是一种具有特异性和口服活性的 SMAD7 反义寡核苷酸。Mongersen 恢复 TGF-β1 活性，从而抑制炎症信号。Mongersen 可以减轻小鼠的克罗恩病样实验性结肠炎。

生物活性

Mongersen (GED-0301) is a specific and orally active SMAD7 antisense oligonucleotide. Mongersen restores TGF-β1 activity leading to inhibition of inflammatory signals. Mongersen can attenuate Crohn's disease-like experimental colitis in mice.

体外研究

体内研究

Mongersen (125 μg/mouse; p.o. twice a week for 3 weeks) reduces TNBS- or DSS-induced colonic inflammation and colonic fibrosis of mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Eight-week-old female BALB/c mice were treated with TNBS
Dosage:	125 μg/mouse
Administration:	Oral gavage, twice a week starting from week 5 or week 9 for 3 weeks
Result:	Reduced Smad7 protein expression. Attenuated the ongoing colonic inflammation. Significantly reduced TNF-α and IL-6 RNA expression. Attenuated colonic fibrosis.

体内研究

Mongersen (125 μg/mouse; p.o. twice a week for 3 weeks) reduces TNBS- or DSS-induced colonic inflammation and colonic fibrosis of mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Eight-week-old female BALB/c mice were treated with TNBS
Dosage:	125 μg/mouse
Administration:	Oral gavage, twice a week starting from week 5 or week 9 for 3 weeks
Result:	Reduced Smad7 protein expression. Attenuated the ongoing colonic inflammation. Significantly reduced TNF-α and IL-6 RNA expression. Attenuated colonic fibrosis.

性状

Solid

溶解性数据

In Vitro:

H₂O : 20 mg/mL (3.04 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	0.1519 mL	0.7594 mL	1.5188 mL
5 mM	---	---	---
10 mM	---	---	---

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

参考文献