NSC668036,99.0%
产品编号：Bellancom-117666| CAS NO：144678-63-7| 分子式：C21H36N2O9| 分子量：460.52
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NSC668036
| 产品介绍 | NSC668036 是一种 Disheveled (Dvl) PDZ 结构域抑制剂，Kd 为 237 µM。NSC668036 通过中断 Frizzled-Dvl 相互作用来阻断 Wnt 信号。 | |||||||||
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| 生物活性 | NSC668036 is a Dishevelled (Dvl) PDZ domain inhibitor with a Kd of 237 µM. NSC668036 blocks Wnt signaling by interrupting the Frizzled-Dvl interaction. | |||||||||
| 体外研究 |
In Xenopus, NSC668036 inhibiteds the signaling induced by Wnt3A. 西域 has not independently confirmed the accuracy of these methods. They are for reference only. | |||||||||
| 体内研究 |
In Bleomycin-induced pulmonary fibrosis murine model, NSC668036 (5 mg/kg) significantly suppresses accumulation of collagen I, α-SMA, and TGF-β1 but increased the expression of CK19, Occludin and E-cadherin that can inhibit pulmonary fibrogenesis. 西域 has not independently confirmed the accuracy of these methods. They are for reference only. | |||||||||
| 体内研究 |
In Bleomycin-induced pulmonary fibrosis murine model, NSC668036 (5 mg/kg) significantly suppresses accumulation of collagen I, α-SMA, and TGF-β1 but increased the expression of CK19, Occludin and E-cadherin that can inhibit pulmonary fibrogenesis. 西域 has not independently confirmed the accuracy of these methods. They are for reference only. | |||||||||
| 性状 | Solid | |||||||||
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| 运输条件 | Room temperature in continental US; may vary elsewhere. | |||||||||
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