Apyramide is an?anti-inflammatory?agent (NSAID) and behaves as a proagent of indomethacin (HY-14397). Indomethacin is a potent, blood-brain permeable and nonselective inhibitor of?COX1?and?COX2.

Apyramide is far less toxic than indomethacin in rats and mice by the oral or the i.p. route. It exhibits anti-inflammatory activity on carrageenin-induced paw oedema, cotton pellet granuloma and adjuvant arthritis, as well as analgesic and antipyretic activities.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Apyramide is far less toxic than indomethacin in rats and mice by the oral or the i.p. route. It exhibits anti-inflammatory activity on carrageenin-induced paw oedema, cotton pellet granuloma and adjuvant arthritis, as well as analgesic and antipyretic activities.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

• . Sauvaire D, et al. Pharmacological activity and toxicity of apyramide: comparison with non-steroidal anti-inflammatory agents. Drugs Exp Clin Res. 1987;13(5):247-52.  [Content Brief]

  . M Cociglio, et al. Pharmacokinetics of an indomethacin pro-drug: apyramide after intravenous administration in dog. Eur J Drug Metab Pharmacokinet. Oct-Dec 1991;16(4):275-80.  [Content Brief]