AZD9898|cas:2042347-69-1|西域试剂

AZD9898,98.62%

产品编号：Bellancom-126329| CAS NO：2042347-69-1| 分子式：C₂₀H₁₉ClF₃N₃O₄| 分子量：457.83

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	包装	价格	库存与货期	购买量	操作
Bellancom-126329		￥9100.00	杭州北京（现货）
Bellancom-126329		￥14500.00	杭州北京（现货）

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AZD9898

产品介绍

AZD9898 是一种口服有效的白三烯-C4 合成酶 (LTC4S) 抑制剂，IC₅₀ 值为 0.28 nM。AZD9898 减轻GABA 结合和肝毒性信号。AZD9898 可用于哮喘的研究。

生物活性

AZD9898 is an orally active leukotriene-C4 synthetase (LTC4S, glutathione S-transferase II) inhibitor, with an IC₅₀ of 0.28 nM. AZD9898 mitigates the GABA binding and hepatic toxicity signal. AZD9898 has the potential to treat asthma.

体外研究

体内研究

AZD9898 with the single dose of 100 mg/kg is well tolerated and no safety concerns are raised.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Rat 6M/group.
Dosage:	10 and 100 mg/kg (for Toxicology Study).
Administration:	Sing oral dose.
Result:	Showed no signs of testicular toxicity, and only adaptive changes in the liver due to cytochrome P450 induction which were not judged adverse, providing a 200 fold margin between the no adverse effect level and the predicted human exposure at the predicted therapeutic dose.

体内研究

AZD9898 with the single dose of 100 mg/kg is well tolerated and no safety concerns are raised.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Rat 6M/group.
Dosage:	10 and 100 mg/kg (for Toxicology Study).
Administration:	Sing oral dose.
Result:	Showed no signs of testicular toxicity, and only adaptive changes in the liver due to cytochrome P450 induction which were not judged adverse, providing a 200 fold margin between the no adverse effect level and the predicted human exposure at the predicted therapeutic dose.

性状

Solid

溶解性数据

In Vitro:

DMSO : ≥ 250 mg/mL (546.05 mM)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.1842 mL	10.9211 mL	21.8422 mL
5 mM	0.4368 mL	2.1842 mL	4.3684 mL
10 mM	0.2184 mL	1.0921 mL	2.1842 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式