Acloproxalap|cas:1824609-67-7|西域试剂

Acloproxalap,98.79%

产品编号：Bellancom-147240| CAS NO：1824609-67-7| 分子式：C₁₂H₁₄N₂O| 分子量：202.25

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货号	价格	库存与货期
Bellancom-147240	￥800.00	杭州北京（现货）
Bellancom-147240	￥1300.00	杭州北京（现货）
Bellancom-147240	￥2650.00	杭州北京（现货）
Bellancom-147240	￥4250.00	杭州北京（现货）
Bellancom-147240	￥6800.00	杭州北京（现货）

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Acloproxalap

产品介绍

Acloproxalap 是一种基于喹啉的醛清除剂，可用于有毒醛积累的疾病研究，如眼部、皮肤等炎症性疾病，肺炎等呼吸系统疾病，器官疾病以及病毒感染相关性综合症等。

生物活性

Acloproxalap is a quinoline-based aldehyde scavenger that can be used in studies of diseases with toxic aldehyde accumulation, such as inflammatory diseases of the eye and skin, respiratory diseases such as pneumonia, organ diseases, and viral infection-related syndromes.

体外研究

体内研究

Acloproxalap (compound I-6) (100 or 200 mg/kg, i.p. or p.o., everyday, 6 days) can effectively improve inflammation of the colon in acute ulcerative colitis (UC) female Swiss Webster mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Acute ulcerative colitis (UC) in female Swiss Webster mice
Dosage:	100 mg/kg, 200 mg/kg
Administration:	Intraperitoneal injection for 100 mg/kg, oral gavage for 200 mg/kg; everyday; 6 days
Result:	Inhibited weight loss in intraperitoneal injection mice significantly while there was no significant difference in the oral gavage group compared to the control group. Both significantly reduced colonic histopathological parameters.

Animal Model:

Male non-naïve beagle dogs

Dosage:

3 mg/kg

Administration:

Intravenous injection; once

Result:

The pharmacokinetic parameters of Acloproxalap (compound I-1)

Parameter	Acloproxalap (compound I-1)
t_1/2	1.82 h
T_max	0.518 h
Clearance	12.2 mL/kg/min
steady-state volume	1385 mL/kg
AUC_0-t	4103 ng/mL*h
AUC_{0‑inf_obs}	4137 ng/mL*h

Animal Model:

Male non-naïve beagle dogs

Dosage:

10 mg/kg

Administration:

Oral gavage; once

Result:

The pharmacokinetic parameters of Acloproxalap (compound I-1)

Parameter	Acloproxalap (compound I-1)
t_1/2	3.02 h
T_max	0.518 h
C_max	3558 ng/mL
AUC_0-t	9361 ng/mL*h
AUC_{0‑inf_obs}	9546 ng/mL*h
BioA	75%

体内研究

Acloproxalap (compound I-6) (100 or 200 mg/kg, i.p. or p.o., everyday, 6 days) can effectively improve inflammation of the colon in acute ulcerative colitis (UC) female Swiss Webster mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Acute ulcerative colitis (UC) in female Swiss Webster mice
Dosage:	100 mg/kg, 200 mg/kg
Administration:	Intraperitoneal injection for 100 mg/kg, oral gavage for 200 mg/kg; everyday; 6 days
Result:	Inhibited weight loss in intraperitoneal injection mice significantly while there was no significant difference in the oral gavage group compared to the control group. Both significantly reduced colonic histopathological parameters.

Animal Model:

Male non-naïve beagle dogs

Dosage:

3 mg/kg

Administration:

Intravenous injection; once

Result:

The pharmacokinetic parameters of Acloproxalap (compound I-1)

Parameter	Acloproxalap (compound I-1)
t_1/2	1.82 h
T_max	0.518 h
Clearance	12.2 mL/kg/min
steady-state volume	1385 mL/kg
AUC_0-t	4103 ng/mL*h
AUC_{0‑inf_obs}	4137 ng/mL*h